Longitudinal analysis of regional cerebellum volumes during normal aging.
Longitudinal analysis of regional cerebellum volumes during normal aging.
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DOI：
10.1016/j.neuroimage.2020.117062
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发表时间：
2020-10-15
期刊：
影响因子：
5.7
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Han, Shuo;An, Yang;Carass, Aaron;Prince, Jerry L.;Resnick, Susan M.
一些横断面研究表明，随着年龄的增长，小脑体积减少，但很少有认知健康的老年人小脑亚区的年龄变化的纵向研究。在这项工作中，分析了来自巴尔的摩老龄化纵向研究（BLSA）的822名认知正常参与者的2,023张磁共振（MR）图像。参与者在基线评估时的年龄范围为50至95岁（平均70.7岁）。随访间隔为1-9年（平均3.7年）的参与者有两个或两个以上的访问。我们使用了最近开发的基于卷积神经网络的小脑分区算法，将小脑分为28个子区域。线性混合效应模型应用于每个小脑亚区的体积，以研究在调整颅内体积后的横截面和纵向年龄效应，以及性别效应及其相互作用。我们的研究结果表明，小脑萎缩的空间变化模式与年龄和性别的横截面和纵向。
Some cross-sectional studies suggest reduced cerebellar volumes with aging, but there have been few longitudinal studies of age changes in cerebellar subregions in cognitively healthy older adults. In this work, 2,023 magnetic resonance (MR) images of 822 cognitively normal participants from the Baltimore Longitudinal Study of Aging (BLSA) were analyzed. Participants ranged in age from 50 to 95 years (mean 70.7 years) at the baseline assessment. Follow-up intervals were 1–9 years (mean 3.7 years) for participants with two or more visits. We used a recently developed cerebellum parcellation algorithm based on convolutional neural networks to divide the cerebellum into 28 subregions. Linear mixed effects models were applied to the volume of each cerebellar subregion to investigate cross-sectional and longitudinal age effects, as well as effects of sex and their interactions, after adjusting for intracranial volume. Our findings suggest spatially varying atrophy patterns across the cerebellum with respect to age and sex both cross-sectionally and longitudinally.
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影响因子：
8.2
作者：
Tian Q;Chastan N;Bair WN;Resnick SM;Ferrucci L;Studenski SA
通讯作者：
Studenski SA
影响因子：
4.8
作者：
Bernard, Jessica A.;Leopold, Daniel R.;Calhoun, Vince D.;Mittal, Vijay A.
通讯作者：
Mittal, Vijay A.
影响因子：
4.2
作者：
Armstrong, Nicole M.;An, Yang;Resnick, Susan M.
通讯作者：
Resnick, Susan M.
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
2.5
作者：
Raz, N;Rodrigue, KM;Acker, JD
通讯作者：
Acker, JD