Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen.
Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen.
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使用非甾体类抗炎药氟比洛芬改变人类牙槽骨流失的进程。
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Paul Goldhaber
中科院分区：
文献类型：
--
作者：
Ray C. Williams;Marjorie K. Jeffcoat;T. Howell;Arturo R. Rolla;Derek F Stubbs;Kok W. Teoh;Michael S. Reddy;Paul Goldhaber
人类牙周病的治疗依赖于对病原细菌的机械和抗菌抑制。通过阻断参与破坏过程的宿主途径来改变牙周炎进展的能力是当前研究的一个领域。前列腺素和花生四烯酸的其他代谢物被认为是牙周炎等疾病骨吸收的重要宿主介质。我们之前已经研究了前列腺素生成抑制剂，非甾体抗炎药（NSAIDs）对抑制小猎犬牙槽骨丢失的作用。本研究旨在研究非甾体抗炎药氟比洛芬对减缓人类牙槽骨放射学损失的影响。我们招募了56名有牙槽骨丢失影像学证据的个体进行研究。44例患者仍在研究中进行牙槽骨丢失的数据分析。经过6个月的基线预处理期，以测量骨质流失的放射学进展，一半的患者服用氟比洛芬，50mg . b.d，而一半的患者服用安慰剂。所有患者每6个月由卫生员进行龈下除垢和浮石治疗。将2年治疗期间的牙槽骨丢失率与患者组内和组间基线6个月预处理期间进行比较。在整个研究过程中，有明显骨丢失的牙齿退出研究并采用常规机械治疗。在预处理期结束时，两组患者的平均牙槽骨丢失率相似。（摘要删节250字）
The treatment of human periodontal diseases relies on mechanical and antimicrobial suppression of the etiologic bacteria. The ability to alter the progression of periodontitis by additionally blocking host pathways involved in the destructive process is an area of current research. Prostaglandins and other metabolites of arachidonic acid are believed to be important host mediators of the bone resorption of diseases such as periodontitis. We have previously examined the effect of inhibitors of prostaglandin production, non-steroidal anti-inflammatory drugs (NSAIDs), on inhibiting alveolar bone loss in beagles. The present study was designed to examine the effect of the NSAID, flurbiprofen, on slowing the radiographic loss of alveolar bone in the human. Fifty-six individuals with radiographic evidence of alveolar bone loss were recruited for study. Forty-four patients remained in the study for the data analysis of loss of alveolar bone. Following a 6 month baseline pretreatment period to measure the radiographic progression of bone loss, half of the patients were administered flurbiprofen, 50 mg. b.i.d., while half were administered a placebo. All patients received a subgingival scaling and pumice by a hygienist every 6 months. The rate of alveolar bone loss in a 2 year treatment period was compared to the baseline 6 month pretreatment period within and between patient groups. Throughout the study, teeth exhibiting obvious loss of bone were exited from study and treated with conventional mechanical therapy. At the end of the pretreatment period both patient groups had a similar mean rate of alveolar bone loss.(ABSTRACT TRUNCATED AT 250 WORDS)
影响因子：
3.5
作者：
Offenbacher,S;Braswell,LD;Loos,AS;Johnson,HG;Hall,CM;McClure,H;Orkin,JL;Strobert,EA;Green,MD;Odle,BM
通讯作者：
Odle,BM
吲哚美辛对实验性牙周炎牙槽骨丢失的影响。
影响因子：
3.5
作者：
Weaks-Dybvig,M;Sanavi,F;Zander,H;Rifkin,BR
通讯作者：
Rifkin,BR
影响因子：
3.5
作者：
OFFENBACHER, S;ODLE, BM;VANDYKE, TE
通讯作者：
VANDYKE, TE