Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection.
Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection.
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DOI：
10.3390/medicina57101079
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发表时间：
2021-10-09
期刊：
影响因子：
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通讯作者：
Córdova A
中科院分区：
文献类型：
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作者：
Caballero-García A;Pérez-Valdecantos D;Guallar P;Caballero-Castillo A;Roche E;Noriega DC;Córdova A
Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection. Materials and Methods: This pilot study was conducted at the Soria Norte Health Center. The study consisted of a double-blind trial with two groups of men (placebo and vitamin D-supplemented) (n = 15/group). Treatment with vitamin D (cholecalciferol: 2000 IU/day) and placebo was carried out for 6 weeks. Circulating hematological and biochemical parameters (total protein, glucose, vitamin D, urea, uric acid, aspartate aminotransferase/glutamic-oxaloacetic transaminase, alanine aminotransferase/glutamic-pyruvic transaminase, creatine kinase, lactate dehydrogenase, aldolase, gamma-glutamyl transferase and myoglobin) and the hormones cortisol and testosterone were determined. As for respiratory function tests, FEV1 and respiratory flow were also studied. For physical fitness tests, the “six-minute walk test” (6MWT) was used. Results: After vitamin D supplementation, we observed that serum creatine kinase levels returned to optimal values. This change suggests a protective role of vitamin D against muscle catabolism compared to placebo. In terms of physical test results, we observed only slight non-significant improvements, although patients reported feeling better. Conclusions: Vitamin D supplementation produces decreases in indicators of muscle damage, which may ultimately contribute to improving the health status and quality of life of patients who have suffered from COVID-19, during the recovery process.
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影响因子：
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作者：
Álvarez-Mon M;Ortega MA;Gasulla Ó;Fortuny-Profitós J;Mazaira-Font FA;Saurina P;Monserrat J;Plana MN;Troncoso D;Moreno JS;Muñoz B;Arranz A;Varona JF;Lopez-Escobar A;Barco AA
通讯作者：
Barco AA
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
38.9
作者：
Lee, Paul;Nair, Priya;Center, Jacqueline R.
通讯作者：
Center, Jacqueline R.
影响因子：
5.9
作者：
Caballero-García A;Córdova-Martínez A;Vicente-Salar N;Roche E;Pérez-Valdecantos D
通讯作者：
Pérez-Valdecantos D
影响因子：
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作者：
Aronson, Jeffrey K;Ferner, Robin E
通讯作者：
Ferner, Robin E