Rearing in an Enriched Environment Ameliorates the ADHD-like Behaviors of Lister Hooded Rats While Suppressing Neuronal Activities in the Medial Prefrontal Cortex.
Rearing in an Enriched Environment Ameliorates the ADHD-like Behaviors of Lister Hooded Rats While Suppressing Neuronal Activities in the Medial Prefrontal Cortex.
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除了遗传因素外，环境因素在注意缺陷多动障碍(ADHD)的发病机制中也起着作用。本研究采用利斯特白头鼠作为ADHD模型动物，评价环境因素对ADHD的影响。雄性LHR幼鼠从出生后第23天开始在4种饲养条件下饲养(4只在标准笼子里，12只在大平笼里，4或12只在丰富的环境中)，直到9周龄。在连续7天的野外试验中，饲养EE但不饲养在大型平笼中会降低LHR的活性。在跌落试验中，大多数饲养在EE中的大鼠保持在高空的圆盘上，而大多数饲养在标准笼子中的大鼠则掉落。RNA测序显示，饲养在EE中的LHR在内侧前额叶皮质的即刻早期基因表达减少。在饲养在EE中的LHR中，CFos表达的神经元数量减少。这些结果表明，在EE中生长可以改善类似ADHD的行为，这种改善是由于mPFC中神经元活动的抑制。
In addition to genetic factors, environmental factors play a role in the pathogenesis of attention deficit/hyperactivity disorder (ADHD). This study used Lister hooded rats (LHRs) as ADHD model animals to evaluate the effects of environmental factors. Male LHR pups were kept in four rearing conditions from postnatal day 23 (4 rats in a standard cage; 12 rats in a large flat cage; and 4 or 12 rats in an enriched environment [EE]) until 9 weeks of age. EE rearing but not rearing in a large flat cage decreased the activity of LHRs in the open field test that was conducted for 7 consecutive days. In the drop test, most rats reared in an EE remained on a disk at a height, whereas most rats reared in a standard cage fell off. RNA sequencing revealed that the immediate-early gene expression in the medial prefrontal cortex of LHRs reared in an EE was reduced. cFos-expressing neurons were reduced in number in LHRs reared in an EE. These results suggest that growing in an EE improves ADHD-like behaviors and that said improvement is due to the suppression of neuronal activity in the mPFC.
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影响因子：
2.9
作者：
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通讯作者：
Cheong, Jae Hoon
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作者：
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DOI：
10.1097/00004583-200405000-00009
发表时间：
2004-05-01
影响因子：
13.3
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影响因子：
2.9
作者：
Beau-Lejdstrom R;Douglas I;Evans SJ;Smeeth L
通讯作者：
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