C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
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C反应蛋白作为住院的Covid-19患者的预后指标。
DOI：
10.1371/journal.pone.0242400
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Emory COVID-19 Quality & Clinical Research Collaborative
中科院分区：
文献类型：
--
作者：
Sharifpour M;Rangaraju S;Liu M;Alabyad D;Nahab FB;Creel-Bulos CM;Jabaley CS;Emory COVID-19 Quality & Clinical Research Collaborative
最近的研究报告称，COVID-19患者的CRP水平升高，可能与疾病的严重程度和疾病进展相关。我们对268名成年患者的医疗记录进行了回顾性队列分析，这些患者被纳入埃默里医疗保健系统的六个COVID ICU之一，并且在入院的前七天内至少有两个CRP值，以研究CRP的时间进展及其与全因住院死亡率的相关性。整个队列住院期间的中位CRP为130 mg/L（IQR 82-191 mg/L），ICU入院时的中位CRP为169（IQR 111-234）。与存活患者相比，死亡患者的住院范围内CRP中位数显著更高[206 mg/L（157-288 mg/L）vs 114 mg/L（72-160 mg/L），p<0.001]。CRP水平在住院的第一周以线性方式增加，并在第5天达到峰值。与死亡患者相比，存活患者的CRP峰值水平较低，下降时间较早。死亡患者的CRP水平显著高于存活患者（p<0.001）。我们的研究结果支持每日CRP值在住院COVID-19患者中的实用性，并提供住院期间的早期阈值，可能有助于风险分层和诊断。
Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82–191 mg/L), and the median CRP on ICU admission was 169 (IQR 111–234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157–288 mg/L) vs 114 mg/L (72–160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.
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SARS患者的临床表现，实验室发现和治疗结果。
影响因子：
11.8
作者：
Wang JT;Sheng WH;Fang CT;Chen YC;Wang JL;Yu CJ;Chang SC;Yang PC
通讯作者：
Yang PC
DOI：
10.1186/s12941-020-00362-2
发表时间：
2020-05-15
影响因子：
5.7
作者：
Chen, Wei;Zheng, Kenneth I.;Qiao, Zengpei
通讯作者：
Qiao, Zengpei
DOI：
10.1007/s00011-018-1188-x
发表时间：
2019-01
期刊：
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
影响因子：
--
作者：
Vasileva D;Badawi A
通讯作者：
Badawi A
影响因子：
3.7
作者：
Koozi, Hazem;Lengquist, Maria;Frigyesi, Attila
通讯作者：
Frigyesi, Attila
影响因子：
8.4
作者：
Velavan, Thirumalaisamy P.;Meyer, Christian G.
通讯作者：
Meyer, Christian G.