Effects of Social Defeat Stress on Sleep in Mice.
Effects of Social Defeat Stress on Sleep in Mice.
复制标题
DOI：
10.3389/fnbeh.2017.00227
复制
发表时间：
2017
影响因子：
3
通讯作者：
Fabre V
中科院分区：
文献类型：
--
作者：
Henderson F;Vialou V;El Mestikawy S;Fabre V
压力在精神疾病的发展中起着关键作用，并对睡眠完整性产生负面影响。在小鼠中，慢性社交失败压力（CSDS）是一种行为学上有效的压力相关疾病模型，但对其对睡眠调节的影响知之甚少。在这里，我们研究了连续10天的社交失败（SD）对C57 Bl/6 J雄性小鼠警觉状态的即时和长期影响。评估社会行为以鉴定易感小鼠，即，发展出长期社交回避的小鼠和不易受影响的小鼠。通过多导睡眠图记录分析两组小鼠在基线、第一、第三和第十次应激后以及10天CSDS后第5个恢复日（R5）的睡眠-觉醒阶段。在易感小鼠中，每个SD阶段产生睡眠-觉醒状态的双相变化，这些变化在整个沿着10天的CSDS中得以保留。这些会议引起了短期的觉醒时间增加，而快速眼动（REM）睡眠被强烈抑制。同时，在非REM（NREM）睡眠期间，δ功率增加。在随后的黑暗期内，在每次分析的SD会话后观察到总睡眠时间增加以及唤醒碎片。在不敏感的小鼠中观察到类似的变化。在R5，升高的高频EEG活动，如在失眠症患者中观察到的，出现在NREM睡眠中的易感和不易感组，表明CSDS损害睡眠质量。此外，易受影响但并非不受影响的小鼠在恢复过程中表现出压力预期唤醒，这是焦虑症的一个共同特征。总之，我们的研究结果表明，CSDS对警觉状态有着深远的影响，并进一步支持睡眠受到压力事件的严格调节。他们还发现，对慢性心理压力的敏感性与高度的唤醒有关，这是压力脆弱性的生理特征。
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance states in C57Bl/6J male mice. Social behavior was assessed to identify susceptible mice, i.e., mice that develop long-lasting social avoidance, and unsusceptible mice. Sleep-wake stages in mice of both groups were analyzed by means of polysomnographic recordings at baseline, after the first, third, and tenth stress sessions and on the 5th recovery day (R5) following the 10-day CSDS. In susceptible mice, each SD session produced biphasic changes in sleep-wake states that were preserved all along 10-day CSDS. These sessions elicited a short-term enhancement of wake time while rapid eye-movement (REM) sleep was strongly inhibited. Concomitantly, delta power was increased during non REM (NREM) sleep. During the following dark period, an increase in total sleep time, as well as wake fragmentation, were observed after each analyzed SD session. Similar changes were observed in unsusceptible mice. At R5, elevated high-frequency EEG activity, as observed in insomniacs, emerged during NREM sleep in both susceptible and unsusceptible groups suggesting that CSDS impaired sleep quality. Furthermore, susceptible but not unsusceptible mice displayed stress-anticipatory arousal during recovery, a common feature of anxiety disorders. Altogether, our findings show that CSDS has profound impacts on vigilance states and further support that sleep is tightly regulated by exposure to stressful events. They also revealed that susceptibility to chronic psychological stress is associated with heightened arousal, a physiological feature of stress vulnerability.
登录
查看更多内容
影响因子：
5.6
作者：
Castro-Faundez, Javiera;Diaz, Javier;Ocampo-Garces, Adrian
通讯作者：
Ocampo-Garces, Adrian
影响因子：
6.7
作者：
Armitage, R.
通讯作者：
Armitage, R.
影响因子：
2.9
作者：
Björkqvist, K
通讯作者：
Björkqvist, K
影响因子：
3.8
作者：
ACHERMANN, P;DIJK, DJ;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
3.3
作者：
España, RA;Valentino, RJ;Berridge, CW
通讯作者：
Berridge, CW