Postural control in bipolar disorder: increased sway area and decreased dynamical complexity.
Postural control in bipolar disorder: increased sway area and decreased dynamical complexity.
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DOI：
10.1371/journal.pone.0019824
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Hetrick WP
中科院分区：
文献类型：
--
作者：
Bolbecker AR;Hong SL;Kent JS;Klaunig MJ;O'Donnell BF;Hetrick WP
在双相情感障碍患者的大脑中已经发现了结构、神经化学和功能异常，包括涉及姿势控制的关键大脑结构，即小脑、脑干和基底神经节。基于这些发现，我们检验了双相情感障碍患者存在姿势控制缺陷的假设。16名双相情感障碍（BD）患者和16名年龄匹配的非精神病健康对照者被要求在4种条件下尽可能静止地站在测力平台上2分钟：（1）睁眼-睁眼基础;（2）闭眼-睁眼基础;（3）睁眼-闭眼基础;（4）闭眼-闭眼基础。姿势摇摆数据被提交到传统的定量分析摇摆面积的大小，使用中心的压力测量。此外，还对数据进行了去趋势波动分析，这是一种非线性动力系统分析技术，可在前后和内外两个方向上测量时间序列的复杂性。双相情感障碍组的摇摆面积增加，表明姿势控制能力下降。在双相情感障碍组中也观察到内外向复杂性降低，这表明他们可用于姿势控制的动态范围减少，并且他们的姿势矫正主要由较长的时间尺度主导。在这两个措施，诊断组和视觉条件之间的显着相互作用也被观察到，这表明BD参与者在他们的能力，使他们的摇摆模式时，没有视觉信息的纠正受损。更大的摇摆幅度和降低的复杂性表明，双相情感障碍患者在感觉运动整合方面存在缺陷，并且可以进行姿势矫正的时间范围缩小。
Structural, neurochemical, and functional abnormalities have been identified in the brains of individuals with bipolar disorder, including in key brain structures implicated in postural control, i.e. the cerebellum, brainstem, and basal ganglia. Given these findings, we tested the hypothesis that postural control deficits are present in individuals with bipolar disorder. Sixteen participants with bipolar disorder (BD) and 16 age-matched non-psychiatric healthy controls were asked to stand as still as possible on a force platform for 2 minutes under 4 conditions: (1) eyes open-open base; (2) eyes closed-open base; (3) eyes open-closed base; and (4) eyes closed-closed base. Postural sway data were submitted to conventional quantitative analyses of the magnitude of sway area using the center of pressure measurement. In addition, data were submitted to detrended fluctuation analysis, a nonlinear dynamical systems analytic technique that measures complexity of a time-series, on both the anterior-posterior and medio-lateral directions. The bipolar disorder group had increased sway area, indicative of reduced postural control. Decreased complexity in the medio-lateral direction was also observed for the bipolar disorder group, suggesting both a reduction in dynamic range available to them for postural control, and that their postural corrections were primarily dominated by longer time-scales. On both of these measures, significant interactions between diagnostic group and visual condition were also observed, suggesting that the BD participants were impaired in their ability to make corrections to their sway pattern when no visual information was available. Greater sway magnitude and reduced complexity suggest that individuals with bipolar disorder have deficits in sensorimotor integration and a reduced range of timescales available on which to make postural corrections.
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DOI：
10.1177/1534582302001003004
发表时间：
2002-09-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
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通讯作者：
Steinmetz, Joseph E
影响因子：
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作者：
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作者：
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Silver, Tobin A.
影响因子：
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作者：
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通讯作者：
Susser, ES
DOI：
10.1089/104454603322724931
发表时间：
2003-12-01
影响因子：
1.9
作者：
Cecil, KM;DelBello, MP;Strakowski, SM
通讯作者：
Strakowski, SM