Time-dependent memory transformation along the hippocampal anterior-posterior axis.
Time-dependent memory transformation along the hippocampal anterior-posterior axis.
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DOI：
10.1038/s41467-018-03661-7
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发表时间：
2018-03-23
影响因子：
16.6
通讯作者：
Schwabe L
中科院分区：
文献类型：
--
作者：
Dandolo LC;Schwabe L
随着时间的推移，记忆经历了一次神经重组，这与细节的、情节性的记忆转化为更语义化的、类似记忆的记忆有关。传统上，这种重组被认为涉及记忆从海马体到新皮层区域的重新分配。在这里，我们报告了海马内的时间依赖性重组，沿着它的前后轴，这与细节记忆转化为gist-like表征有关。我们发现，在前海马区的记忆表征是高度不同的，前海马区的活动与详细的记忆，但随着时间的推移而减少。然而，后海马的代表，更像是在以后的保留间隔，并不随着时间的推移而下降。这些发现表明，除了众所周知的从海马到新皮层的系统整合之外，海马内的变化对记忆的时间动态至关重要。随着时间的推移，详细的记忆会转变为类似于记忆的记忆。在这里，作者报告说，这种变化与海马体内的时间依赖性重组有关，因此支持记忆特异性的前部活动随着时间的推移而下降，而携带要点表征的后部活动模式保持更稳定。
With time, memories undergo a neural reorganization that is linked to a transformation of detailed, episodic into more semantic, gist-like memory. Traditionally, this reorganization is thought to involve a redistribution of memory from the hippocampus to neocortical areas. Here we report a time-dependent reorganization within the hippocampus, along its anterior–posterior axis, that is related to the transformation of detailed memories into gist-like representations. We show that mnemonic representations in the anterior hippocampus are highly distinct and that anterior hippocampal activity is associated with detailed memory but decreases over time. Posterior hippocampal representations, however, are more gist-like at a later retention interval, and do not decline over time. These findings indicate that, in addition to the well-known systems consolidation from hippocampus to neocortex, there are changes within the hippocampus that are crucial for the temporal dynamics of memory. Detailed memories are transformed into gist-like memories over time. Here, the authors report that this change is linked to a time-dependent reorganization within the hippocampus, such that anterior activity supporting memory specificity declines over time while posterior activity patterns carrying gist representations remain more stable.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
4.3
作者：
Nili H;Wingfield C;Walther A;Su L;Marslen-Wilson W;Kriegeskorte N
通讯作者：
Kriegeskorte N
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
9.2
作者：
Milivojevic, Branka;Vicente-Grabovetsky, Alejandro;Doeller, Christian F.
通讯作者：
Doeller, Christian F.
DOI：
10.1016/j.cub.2010.01.053
发表时间：
2010-03-23
期刊：
Current biology : CB
影响因子：
--
作者：
Chadwick MJ;Hassabis D;Weiskopf N;Maguire EA
通讯作者：
Maguire EA