Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
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DOI：
10.1002/cncr.27538
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发表时间：
2012-11-01
期刊：
影响因子：
6.2
通讯作者：
Wiemels, Joseph
中科院分区：
文献类型：
--
作者：
Bracci, Paige M.;Zhou, Mi;Young, Scott;Wiemels, Joseph
胰腺癌缺乏筛查和早期诊断工具;大多数患者被诊断为转移性疾病。肿瘤相关抗原（TAAs）的自身抗体可以在诊断前数月至数年出现，并有望作为早期检测的生物标志物。在旧金山弗朗西斯科湾区进行的一项基于人群的病例对照胰腺癌研究中，在参与者（病例=300，对照=300）的血清中评价了胰腺癌自身抗体CTDSP 1、MAPK 9和NR 2 E3的TAA，这些抗体在探索性研究中被确定为潜在有希望的生物标志物。患者通过癌症登记处快速病例确定，从1995-1999年新诊断并随访至2008年。自身抗体水平作为连续和分组（四分位数）变量进行分析。多变量非条件logistic回归用于计算比值比（OR），作为与疾病状态相关的自身抗体水平的估计值。Kaplan-Meier乘积限估计和多变量考克斯比例风险回归用于评估与病例生存时间相关的自身抗体水平。病例的CTDSP 1（P=0.004）、MAPK 9（P=0.0002）和NR 2 E3（P≤0.0001）自身抗体水平高于对照组（第四与第一四分位数：CTDSP 1 OR=1.7，MAPK 9 OR=2.5，NR 2 E3 OR=4.0）。高BMI和吸烟与对照组的水平相关，但不是统计学混杂因素。高CTDSP 1水平与更好的生存率有一定的相关性（HR=0.77，P=0.07）。结合先前的结果，我们的研究提供了证据，表明癌症相关的宿主免疫反应因子可能是胰腺癌有用的诊断筛选工具和预后指标。需要进一步的研究来严格评估TAA自身抗体组在胰腺癌和其他癌症的诊断筛查、预后和免疫治疗中的价值。
Screening and early diagnosis tools are lacking for pancreatic adenocarcinoma; most patients are diagnosed with metastatic disease. Autoantibodies to tumor-associated antigens (TAAs) can be present months to years before diagnosis and hold promise as biomarkers for early detection. TAAs to pancreatic cancer autoantibodies CTDSP1, MAPK9, and NR2E3, identified as potentially promising biomarkers in exploratory studies, were evaluated in serum from participants (cases=300, controls=300) in a population-based case-control pancreatic cancer study in the San Francisco Bay Area. Patients were identified through cancer registry rapid case ascertainment, newly diagnosed from 1995-1999 and followed-up through 2008. Autoantibody levels were analyzed as continuous and grouped (quartiles) variables. Multivariable unconditional logistic regression was used to compute odds ratios (OR) as estimates of autoantibody levels associated with disease status. Kaplan-Meier product limit estimates and multivariable Cox proportional hazards regression were used to assess autoantibody levels associated with case survival duration. Cases had higher levels of CTDSP1 (P=0.004), MAPK9 (P=0.0002), and NR2E3 (P≤0.0001) autoantibodies than controls (4th vs. 1st quartile:CTDSP1 OR=1.7, MAPK9 OR=2.5, NR2E3 OR=4.0). High BMI and tobacco use were associated with levels in controls but were not statistical confounders. High CTDSP1 levels were somewhat associated with better survival (HR=0.77, P=0.07). Combined with previous results, our study contributes evidence that cancer-related host immune-response factors may be useful diagnostic screening tools and prognostic indicators for pancreatic cancer. Further studies are needed to critically assess the value of autoantibody panels to TAAs in diagnostic screening, prognosis and immunotherapy of pancreatic and other cancers.
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影响因子：
4.4
作者：
Li, Chen;Simeone, Diane M.;Brenner, Dean E.;Anderson, Michelle A.;Shedden, Kerby A.;Ruffin, Mack T.;Lubman, David M.
通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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