Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.
Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.
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DOI：
10.1016/j.cmet.2013.08.007
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发表时间：
2013-09-03
期刊：
影响因子：
29
通讯作者：
Xu XZ
中科院分区：
文献类型：
--
作者：
Liu J;Zhang B;Lei H;Feng Z;Liu J;Hsu AL;Xu XZ
衰老的特征是多种生理功能的进行性下降（即功能性衰老）。随着动物年龄的增长，它们的运动活动逐渐丧失，但其潜在机制仍不清楚。这里我们用C语言来处理这个问题。elegans通过功能上表征其老化的神经系统和肌肉。我们发现，运动神经元表现出一个渐进的功能衰退，在生命的早期开始。令人惊讶的是，以前被认为会经历功能性衰老的体壁肌肉，直到中晚期才表现出这种衰退。值得注意的是，运动神经元首先在突触囊泡融合中出现缺陷，然后是量子大小和囊泡对接/启动，揭示了突触传递中的特定功能退化。突触传递的药物刺激可以改善老年动物的运动活性。这些结果揭示了神经系统在C. elegans和提供洞察如何功能老化发生在这个有机体。
Aging is characterized by a progressive decline in multiple physiological functions (i.e. functional aging). As animals age, they exhibit a gradual loss in motor activity, but the underlying mechanisms remain unclear. Here we approach this question in C. elegans by functionally characterizing its aging nervous system and muscles. We find that motor neurons exhibit a progressive functional decline, beginning in early life. Surprisingly, body-wall muscles, which are previously thought to undergo functional aging, do not manifest such a decline until mid-late life. Notably, motor neurons first develop a deficit in synaptic vesicle fusion followed by that in quantal size and vesicle docking/priming, revealing specific functional deteriorations in synaptic transmission. Pharmacological stimulation of synaptic transmission can improve motor activity in aged animals. These results uncover a critical role for the nervous system in age-dependent motor activity decline in C. elegans and provide insights into how functional aging occurs in this organism.
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DOI：
10.1073/pnas.0400848101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
3.9
作者：
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影响因子：
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作者：
Dillin, A;Hsu, AL;Kenyon, C
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