Weight, inflammation, cancer-related symptoms and health related quality of life among breast cancer survivors.
Weight, inflammation, cancer-related symptoms and health related quality of life among breast cancer survivors.
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DOI：
10.1007/s10549-013-2594-y
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发表时间：
2013-07
影响因子：
3.8
通讯作者：
McTiernan, Anne
中科院分区：
文献类型：
--
作者：
Imayama, Ikuyo;Alfano, Catherine M.;Neuhouser, Marian L.;George, Stephanie M.;Smith, Ashley Wilder;Baumgartner, Richard N.;Baumgartner, Kathy B.;Bernstein, Leslie;Wang, Ching-Yun;Duggan, Catherine;Ballard-Barbash, Rachel;McTiernan, Anne
Maintaining weight is important for better prognosis of breast cancer survivors. The associations between weight and cancer-related symptoms are not known. We examined associations among weight, weight change, inflammation, cancer-related symptoms, and health-related quality of life (HRQOL) in a cohort of stage 0-IIIA breast cancer survivors. Participants were recruited on average 6 months (2–12 months) after diagnosis. Height, weight, and c-reactive protein (CRP) were assessed at approximately 30 months post-diagnosis; cancer-related symptoms (chest wall and arm symptoms, vasomotor symptoms, urinary incontinence, vaginal symptoms, cognition/mood problems, sleep, sexual interest/function), and HRQOL (SF-36) were assessed at approximately 40 months post-diagnosis. Weight was measured at baseline in a subset. Data on 661 participants were evaluable for body mass index (BMI); 483 were evaluable for weight change. We assessed associations between BMI (<25.0, 25.0–29.9, ≥30.0 kg/m2), post-diagnosis weight change (lost ≥5%, weight change <5%, gained ≥5%), and CRP (tertile) with cancer-related symptoms and HRQOL using analysis of covariance (ANCOVA). Higher symptoms scores indicate more frequent or severe symptoms. Higher HRQOL scores indicate better HRQOL. Compared with those with BMI<25kg/m2, women with BMI ≥30 kg/m2 had scores that were: increased for arm symptoms (+25.0%), urinary incontinence (+40.0%), tendency to nap (+18.9%) and poorer physical functioning (−15.6%, all p<0.05). Obese women had lower scores in trouble falling asleep (−9.9%; p<0.05). Compared with weight change <5%, participants with ≥5% weight gain had lower scores in physical functioning (−7.2%), role-physical (−15.5%) and vitality (−11.2%), and those with weight loss ≥5% had lower chest wall (−33.0%) and arm symptom scores (−35.5%, all p<0.05). Increasing CRP tertile was associated with worse scores for chest wall symptoms, urinary incontinence, physical functioning, role-physical, vitality and physical component summary scores (all Ptrend<0.05). Future studies should examine whether interventions to maintain a healthy weight and reduce inflammation could alleviate cancer-related symptoms and improve HRQOL.
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影响因子：
45.3
作者：
Caan, Bette J.;Emond, Jennifer A.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
120.7
作者：
Gartner, Rune;Jensen, Maj-Britt;Kehlet, Henrik
通讯作者：
Kehlet, Henrik
DOI：
10.1007/s11764-007-0014-1
发表时间：
2007-06-01
期刊：
Journal of cancer survivorship : research and practice
影响因子：
--
作者：
Alfano, Catherine M;Smith, Ashley Wilder;McTiernan, Anne
通讯作者：
McTiernan, Anne
影响因子：
45.3
作者：
Irwin, ML;McTiernan, A;Ballard-Barbash, R
通讯作者：
Ballard-Barbash, R
影响因子：
3.3
作者：
Bower, JE;Ganz, PA;Fahey, JL
通讯作者：
Fahey, JL