Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.
Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.
复制标题
精神分裂症的额神经代谢产物变化及其与认知控制的关联：系统评价。
DOI：
10.1016/j.neubiorev.2021.11.010
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发表时间：
2022-01
影响因子：
8.2
通讯作者：
Danielmeier C
中科院分区：
文献类型：
--
作者：
Dixon BJ;Kumar J;Danielmeier C
精神分裂症患者内侧额叶脑区GABA水平降低。慢性病患者的内侧和外侧额叶谷氨酸水平较低。工作记忆表现与额叶GABA和Glu有关。预测误差与Glu和内侧额叶GABA有关。处理速度与内侧额叶GABA水平相关。很大一部分精神分裂症患者表现出认知控制功能的缺陷，包括工作记忆、处理速度和抑制控制，这些功能与额叶脑区相关。在这篇系统性综述中，我们调查了慢性精神分裂症患者、首发（FEP）患者和健康对照组之间额叶脑区GABA、谷氨酸、谷氨酰胺和Glx神经代谢物水平的差异。此外，我们回顾了认知控制功能或阴性症状与这些神经代谢物水平之间的相关性。几项研究报告额叶区域的GABA或谷氨酸浓度降低，特别是在慢性精神分裂症患者中，而FEP患者的结果好坏参半。工作记忆表现和预测错误与额叶GABA和谷氨酸水平相关，慢性患者的加工速度与额叶内侧GABA水平相关。代谢物和阴性症状严重程度之间的关系有些不一致。未来的研究在比较精神分裂症患者和健康对照者之间的神经代谢物水平时，应考虑参与者的年龄，药物治疗状态或反应性，疾病阶段和体素的精确解剖位置。
GABA levels are decreased in medial frontal brain areas of schizophrenia patients. Glutamate levels are lower in medial and lateral frontal areas in chronic patients. Working memory performance is associated with frontal GABA and Glu. Prediction errors are associated Glu and medial frontal GABA. Processing speed correlates with medial frontal GABA levels. A large proportion of patients with schizophrenia exhibit deficits in cognitive control functions including working memory, processing speed and inhibitory control, which have been associated with frontal brain areas. In this systematic review, we investigated differences between chronic schizophrenia patients, first-episode (FEP) patients and healthy control groups in the neurometabolite levels of GABA, glutamate, glutamine and Glx in frontal brain areas. Additionally, we reviewed correlations between cognitive control functions or negative symptoms and these neurometabolite levels. Several studies reported decreased GABA or glutamate concentrations in frontal lobe areas, particularly in chronic schizophrenia patients, while the results were mixed for FEP patients. Working memory performance and prediction errors have been associated with frontal GABA and glutamate levels, and processing speed with frontomedial GABA levels in chronic patients. The relationship between metabolites and negative symptom severity was somewhat inconsistent. Future studies should take the participants' age, medication status or responsivity, disease stage and precise anatomical location of the voxel into account when comparing neurometabolite levels between schizophrenia patients and healthy controls.
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DOI：
10.1038/s41386-021-01132-0
发表时间：
2022-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Friedman NP;Robbins TW
通讯作者：
Robbins TW
影响因子：
11
作者：
通讯作者：
--
影响因子：
4.7
作者：
Cadena, Elyse J.;White, David M.;Lahti, Adrienne C.
通讯作者：
Lahti, Adrienne C.
影响因子：
7.6
作者：
Chiappelli, Joshua;Rowland, Laura M.;Hong, L. Elliot
通讯作者：
Hong, L. Elliot
影响因子：
4.7
作者：
Egerton A;Bhachu A;Merritt K;McQueen G;Szulc A;McGuire P
通讯作者：
McGuire P