B cell function and influenza vaccine responses in healthy aging and disease.

B cell function and influenza vaccine responses in healthy aging and disease.
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DOI:
10.1016/j.coi.2014.05.008
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发表时间:
2014-08
影响因子:
7
通讯作者:
Blomberg, Bonnie B.
Blomberg, Bonnie B.
中科院分区:
医学2区
文献类型:
--
作者:
Frasca, Daniela;Blomberg, Bonnie B.

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与年轻人相比,老年人接种流感疫苗的效果较差。一些研究涉及识别能够监测或预测对疫苗的保护性体液免疫反应的免疫生物标记物。在这篇综述中,我们总结了这些数据,重点是年龄对健康个体和2型糖尿病、艾滋病毒和心血管疾病患者的流感疫苗特异性B细胞反应的影响。
Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.
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