Nicotine enhances contextual fear memory reconsolidation in rats
Nicotine enhances contextual fear memory reconsolidation in rats
复制标题
尼古丁增强大鼠情境恐惧记忆再巩固
DOI：
10.1016/j.neulet.2010.10.058
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
Yufeng Yang
中科院分区：
文献类型：
--
作者：
Shaowen Tian (田绍文）;Peng Li;Fulian Huang;Shouhong Zhou;Haifeng Deng;Zhenbang Li;Yufeng Yang
越来越多的证据表明尼古丁与学习和记忆有关。然而，目前还没有研究探索尼古丁和记忆再巩固之间的关系。在本研究中，我们测试了尼古丁对大鼠情境恐惧记忆再巩固的影响。行为过程包括四个训练阶段：习惯化（第0天）、恐惧调节（第1天）、再激活（第2天）和测试（第3天）。再激活后立即注射生理盐水或烟碱（0.25、0.5和1.0mg/kg）。冻结时间的百分比被用来测量条件恐惧反应。结果显示，与生理盐水大鼠相比，1.0mg/kg尼古丁组大鼠在第3天的冰冻反应显著增加。1.0mg/kg尼古丁在激活后6h注射无效。进一步的结果表明，1.0mg/kg尼古丁诱导的冷冻反应增强依赖于恐惧记忆的再巩固，而不是尼古丁给药后24h非特异性冷冻反应的增强。结果表明，在重新激活后立即给予尼古丁可以增强情境恐惧记忆的再巩固。我们目前的发现扩展了之前关于尼古丁对学习和记忆影响的研究。
There is increasing evidence that nicotine is involved in learning and memory. However, there remains no study that has explored the relationship between nicotine and memory reconsolidation. At present study, we tested the effects of nicotine on the reconsolidation of contextual fear memory in rats. Behavior procedure involved four training phases: habituation (Day 0), fear conditioning (Day 1), reactivation (Day 2) and test (Day 3). Rats were injected saline or nicotine (0.25, 0.5 and 1.0mg/kg) immediately after reactivation. Percent of time spent freezing was used to measure conditioned fear response. Results showed that compared with saline rats, rats with nicotine at 1.0mg/kg presented a significant increase of freezing response on Day 3. Nicotine at 1.0mg/kg was ineffective when injected 6h after reactivation. Further results showed that the enhancement of freezing response induced by nicotine at 1.0mg/kg was dependent on fear memory reconsolidation, and was not attributed to an enhancement of the nonspecific freezing response 24h after nicotine administration. The results suggest that nicotine administration immediately after reactivation enhances contextual fear memory reconsolidation. Our present finding extends previous research on the nicotinic effects on learning and memory.
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影响因子：
2.7
作者：
French, KL;Granholm, ACE;Bimonte-Nelson, HA
通讯作者：
Bimonte-Nelson, HA
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
2.7
作者：
Gould, TJ;Higgins, JS
通讯作者：
Higgins, JS
影响因子：
64.8
作者：
Nader, K;Schafe, GE;Le Doux, JE
通讯作者：
Le Doux, JE
DOI：
10.1080/14622200125450
发表时间：
2001-02
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
T. Gould;A. C. Collins;J. M. Wehner
通讯作者：
T. Gould;A. C. Collins;J. M. Wehner