Semi-automated method for estimating lesion volumes.
Semi-automated method for estimating lesion volumes.
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DOI:
10.1016/j.jneumeth.2012.12.010
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发表时间:
2013-02-15
影响因子:
3
通讯作者:
Gale, John T.
中科院分区:
文献类型:
--
作者:
Park, Hyun-Joo;Machado, Andre G.;Cooperrider, Jessica;Havan Truong-Furmaga;Johnson, Matthew;Krishna, Vibhuti;Chen, Zhihong;Gale, John T.
Accurately measuring the volume of tissue damage in experimental lesion models is crucial to adequately control for the extent and location of the lesion, variables that can dramatically bias the outcome of preclinical studies. Many of the current commonly used techniques for this assessment, such as measuring the lesion volume with primitive software macros and plotting the lesion location manually using atlases, are time-consuming and offer limited precision. Here we present an easy to use semi-automated computational method for determining lesion volume and location, designed to increase precision and reduce the manual labor required. We compared this novel method to currently used methods and demonstrate that this tool is comparable or superior to current techniques in terms of precision and has distinct advantages with respect to user interface, labor intensiveness and quality of data presentation.
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影响因子:
5.3
作者:
Baker, Kenneth B.;Schuster, Daniel;Cooperrider, Jessica;Machado, Andre G.
通讯作者:
Machado, Andre G.
影响因子:
2.9
作者:
Machado AG;Baker KB;Schuster D;Butler RS;Rezai A
通讯作者:
Rezai A
影响因子:
8.3
作者:
Lee, VM;Burdett, NG;James, MF
通讯作者:
James, MF
影响因子:
5.3
作者:
Darling, Warren G.;Pizzimenti, Marc A.;Morecraft, Robert J.
通讯作者:
Morecraft, Robert J.
影响因子:
5.8
作者:
Bagnato, Francesca;Ikonomidou, Vasiliki N.;Duyn, Jeff
通讯作者:
Duyn, Jeff