Treg functional stability and its responsiveness to the microenvironment.
Treg functional stability and its responsiveness to the microenvironment.
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DOI：
10.1111/imr.12172
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发表时间：
2014-05
影响因子：
8.7
通讯作者：
Pan F
中科院分区：
文献类型：
--
作者：
Barbi J;Pardoll D;Pan F
调节性 T 细胞 (Treg) 通过其抑制功能防止过度或不必要的免疫激活导致的自身免疫和组织损伤。虽然它们对于适当免疫控制的重要性是不可否认的，但 Treg 谱系的稳定性最近成为一个有争议的话题。许多报告表明，在各种炎症条件下，标志性 Treg 转录因子 Forkhead box 蛋白 3 (Foxp3) 和 Treg 功能都会急剧丧失。最近的其他研究表明，大多数 Tregs 在 Foxp3 表达和抑制功能保留方面具有极强的弹性。虽然这场争论不太可能在不久的将来得到解决，但加深对 Foxp3+ Treg 群体内相当大的异质性以及 Treg 子集如何响应各种环境线索的理解可能是达成和解的关键。在这篇综述中，我们讨论了观察到的 Foxp3+ Treg 身份和功能的稳定性或不稳定性的不同机制。其中包括转录和表观遗传程序、转录靶向和翻译后修饰，这些修饰似乎对微环境的众多元素有反应。这些 Treg 功能调节机制增加了对 Treg 稳定性的讨论。
Regulatory T cells (Tregs) prevent autoimmunity and tissue damage resulting from excessive or unnecessary immune activation through their suppressive function. While their importance for proper immune control is undeniable, the stability of the Treg lineage has recently become a controversial topic. Many reports have shown dramatic loss of the signature Treg transcription factor Forkhead box protein 3 (Foxp3) and Treg function under various inflammatory conditions. Other recent studies demonstrate that most Tregs are extremely resilient in their expression of Foxp3 and the retention of suppressive function. While this debate is unlikely to be settled in the immediate future, improved understanding of the considerable heterogeneity within the Foxp3+ Treg population and how Treg subsets respond to ranging environmental cues may be keys to reconciliation. In this review, we discuss the diverse mechanisms responsible for the observed stability or instability of Foxp3+ Treg identity and function. These include transcriptional and epigenetic programs, transcript targeting and posttranslational modifications that appear responsive to numerous elements of the microenvironment. These mechanisms for Treg functional modulation add to the discussion of Treg stability.
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影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
影响因子：
20.3
作者：
Cejas, Pedro J.;Walsh, Matthew C.;Choi, Yongwon
通讯作者：
Choi, Yongwon
影响因子：
9
作者：
Su, Jin;Liu, Yun-Cai
通讯作者：
Liu, Yun-Cai
影响因子：
30.5
作者：
Boone, DL;Turer, EE;Ma, A
通讯作者：
Ma, A
DOI：
10.4049/jimmunol.0903412
发表时间：
2010-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Caretto D;Katzman SD;Villarino AV;Gallo E;Abbas AK
通讯作者：
Abbas AK