Effects of Sexual Experience and Puberty on Mouse Genital Cortex revealed by Chronic Imaging
Effects of Sexual Experience and Puberty on Mouse Genital Cortex revealed by Chronic Imaging
复制标题
慢性成像揭示性经历和青春期对小鼠生殖皮质的影响
DOI：
10.1016/j.cub.2019.08.062
复制
发表时间：
2019
期刊：
影响因子：
9.2
通讯作者：
Brecht M
中科院分区：
文献类型：
--
作者：
Sigl-Glöckner J;Maier E;Takahashi N;Sachdev R;Larkum M;Brecht M
躯体感觉皮层第4层的地形图通常在生后早期就已确定，此后趋于稳定。然而，生殖器皮层经历了性激素和性接触依赖的青春期扩张。在这里，我们的图像青春期发育的生殖皮质在Scnn 1a-Tg 3-Cre小鼠，转基因表达已被证明是有限的第4层神经元与初级感觉皮质的身份。有趣的是，在青春期，生殖器皮质内的Scnn 1a+神经元数量大约翻了一番。Scnn 1a+神经元的增加是逐渐的，并通过最初的性经验迅速推进。获得Scnn 1a表达的神经元包括第4层的星状和锥体神经元。与新生儿发育不同，金字塔在青春期没有缩回顶端树突。钙成像显示更强的生殖器触摸反应在Scnn 1a+神经元的男性与女性和女性的反应性的发展增加。第一次性互动是一种独特的身体体验，通常会产生持久的记忆。我们认为，这种经验独特地改变了体感身体地图。
The topographic map in layer 4 of somatosensory cortex is usually specified early postnatally and stable thereafter. Genital cortex, however, undergoes a sex-hormone- and sexual-touch-dependent pubertal expansion. Here, we image pubertal development of genital cortex in Scnn1a-Tg3-Cre mice, where transgene expression has been shown to be restricted to layer 4 neurons with primary sensory cortex identity. Interestingly, during puberty, the number of Scnn1a+ neurons roughly doubled within genital cortex. The increase of Scnn1a+ neurons was gradual and rapidly advanced by initial sexual experience. Neurons that gained Scnn1a expression comprised stellate and pyramidal neurons in layer 4. Unlike during neonatal development, pyramids did not retract their apical dendrites during puberty. Calcium imaging revealed stronger genital-touch responses in Scnn1a+ neurons in males versus females and a developmental increase in responsiveness in females. The first sexual interaction is a unique physical experience that often creates long-lasting memories. We suggest such experience uniquely alters somatosensory body maps.
登录
查看更多内容
雄性诱导雌性小鼠青春期：社会线索协同作用的证据。
影响因子：
3.6
作者：
F. Bronson;J. Maruniak
通讯作者：
J. Maruniak
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
影响因子：
4.6
作者：
Gaytan F;Morales C;Leon S;Heras V;Barroso A;Avendaño MS;Vazquez MJ;Castellano JM;Roa J;Tena-Sempere M
通讯作者：
Tena-Sempere M
影响因子：
16.2
作者：
Lenschow, Constanze;Brecht, Michael
通讯作者：
Brecht, Michael
影响因子：
5.7
作者：
Simi, Alessandro;Studer, Michele
通讯作者：
Studer, Michele