Patient understanding of pharmacogenomic test results in clinical care.
Patient understanding of pharmacogenomic test results in clinical care.
复制标题
临床护理中患者对药物基因组学测试结果的了解。
DOI：
10.1016/j.pec.2023.107904
复制
发表时间：
2023
影响因子：
3.5
通讯作者：
Schwartz,PeterH
中科院分区：
文献类型：
--
作者：
Doyle,TomA;Schmidt,KarenK;Halverson,ColinME;Olivera,Jesus;Garcia,Abigail;Shugg,TylerA;Skaar,ToddC;Schwartz,PeterH
目的之前的研究尚未客观评估患者对其药物基因组测试结果的理解程度。在这项研究中，我们评估了对接受过细胞色素 P450 2C19 (CYP2C19) 药物基因组测试的患者的了解。方法 31 对心导管术后接受 CYP2C19 测试的患者进行半结构化访谈，并收到了解释其结果的小册子、信件和钱包卡。用描述性统计总结了李克特和二元问题的答案。使用扎根理论方法对定性数据进行分析，特别注重分类。结果没有参与者知道测试基因的名称或其代谢状态。七名参与者 (23%) 知道测试是否发现任何药物在标准剂量下会降低疗效或增加副作用（“充分了解”）。四名参与者 (13%) 从收到的信件或钱包卡中读取了结果，但没有独立的理解（“依赖书面材料”）。十名参与者记得收到过书面材料（32%）。结论大多数接受过 CYP2C19 PGx 测试的参与者对他们的结果没有最低限度的理解，并且无法将其传达给未来的提供者。实践意义有必要进行进一步的研究，以提高患者对 PGx 测试及其结果的理解，可能通过改善患者与提供者的沟通。
ObjectivePrevious research has not objectively assessed patients’ comprehension of their pharmacogenomic test results. In this study we assessed understanding of patients who had undergone cytochrome P450 2C19 (CYP2C19) pharmacogenomic testing.Methods31 semi-structured interviews with patients who underwent CYP2C19 testing after cardiac catheterization and had been sent a brochure, letter, and wallet card explaining their results. Answers to Likert and binary questions were summarized with descriptive statistics. Qualitative data were analyzed using a grounded theory approach, with particular focus on categorization.ResultsNo participants knew the name of the gene tested or their metabolizer status. Seven participants (23%) knew whether the testing identified any medications that would have lower effectiveness or increased adverse effects for them at standard doses (“Adequate Understanding”). Four participants (13%) read their results from the letter or wallet card they received but had no independent understanding (“Reliant on Written Materials”). Ten participants remembered receiving the written materials (32%).ConclusionA majority of participants who had undergone CYP2C19 PGx testing did not understand their results at even a minimal level and would be unable to communicate them to future providers.Practice implicationsFurther research is necessary to improve patient understanding of PGx testing and their results, potentially through improving patient-provider communication.
登录
查看更多内容
书面信息可提高患者对植入端口的了解。
影响因子：
1.1
作者：
M. Piredda;A. Migliozzi;V. Biagioli;M. Carassiti;M. D. De Marinis
通讯作者：
M. D. De Marinis
回教方法在患者教育和健康结果中的使用和有效性。
DOI：
--
发表时间：
2019
期刊：
Federal practitioner : for the health care professionals of the VA, DoD, and PHS
影响因子：
--
作者：
P. H. Yen;A. Leasure
通讯作者：
A. Leasure
越南语书面和口头医学信息对越南语澳大利亚人的知识和满意度的影响。
影响因子：
3.4
作者：
A. Mai;P. Aslani
通讯作者：
P. Aslani
批判神经科学和社会扩展思维
DOI：
--
发表时间：
2015
期刊：
影响因子：
--
作者：
J. Slaby;S. Gallagher
通讯作者：
S. Gallagher
DOI：
10.3390/pharmacy8030163
发表时间：
2020-09-03
期刊：
Pharmacy (Basel, Switzerland)
影响因子：
--
作者：
Guy JW;Patel I;Oestreich JH
通讯作者：
Oestreich JH