Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack.
Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack.
复制标题
低血清白蛋白水平预示急性缺血性中风或短暂性脑缺血发作患者预后不良
DOI：
10.1136/svn-2020-000676
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发表时间：
2021-09
影响因子：
5.9
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhou H;Wang A;Meng X;Lin J;Jiang Y;Jing J;Zuo Y;Wang Y;Zhao X;Li H;Wang Y
研究急性缺血性卒中（AIS）或短暂性缺血性发作（TIA）患者血清白蛋白与功能不良结局和死亡率的关系，并进行荟萃分析以总结其相关性。我们分析了来自第三个中国卒中登记中心（CNSR-Ⅲ）的数据。根据入院时血清白蛋白水平将患者分为四组。结果包括功能差（改良Rankin量表（mRS）评分为3 - 6）和3个月和1年的死亡率。分别采用多元logistic回归模型和Cox回归模型对相关性进行评价。在meta分析中，我们使用固定效应模型计算功能不良预后的风险比，使用随机效应模型计算死亡率。共有13 618名患者入组。在3个月的随访期间，与40 ~ 44.9 g/L组相比，<35 g/L组患者功能不良结局和死亡风险增加(调整OR 1.37 (95% CI 1.12 ~ 1.67)；调整后危险度2.13 (95% CI 1.41 - 3.23))。每10 g/L血清白蛋白降低与预后的关系始终呈负相关(校正OR为1.17 (95% CI 1.01 ~ 1.35)；调整后的HR 1.86 (95% CI 1.30至2.64))。此外，低血清白蛋白水平与1年的临床结果独立相关。在荟萃分析中，每减少1 g/L， 3个研究的功能不良结果的OR为1.03 (95% CI 1.02至1.05)，5个研究的死亡率的HR为1.07 （95% CI 1.03至1.11）。低血清白蛋白水平可预测AIS或TIA患者的不良功能结局和死亡率。
To examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association. We analysed data from the Third China National Stroke Registry (CNSR-Ⅲ). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis. A total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in <35 g/L group had an increased risk of poor functional outcome and mortality (adjusted OR 1.37 (95% CI 1.12 to 1.67); adjusted HR 2.13 (95% CI 1.41 to 3.23)). The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed (adjusted OR 1.17 (95% CI 1.01 to 1.35); adjusted HR 1.86 (95% CI 1.30 to 2.64)). Also, low serum albumin levels were independently correlated with clinical outcomes at 1 year. In the meta-analysis, the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03 (95% CI 1.02 to 1.05), and the HR for mortality pooled 5 studies was 1.07 (95% CI 1.03 to 1.11). Low serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA.
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