A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease.
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease.
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微生物组网络对非酒精性脂肪肝患者运动和饮食干预反应的随机对照试验
DOI：
10.1038/s41467-022-29968-0
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发表时间：
2022-05-10
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
运动和饮食是非酒精性脂肪肝 (NAFLD) 和糖尿病前期的治疗方法，然而，运动和饮食干预如何影响患者的肠道微生物群尚不完全清楚。我们之前报道了对 NAFLD 和糖尿病前期患者进行的一项为期 8.6 个月的四组（有氧运动，n= 29；饮食，n= 28；有氧运动 + 饮食，n= 29；无干预，n= 29）随机、单盲（研究人员）和对照干预，以评估干预措施对肝脏脂肪含量和葡萄糖代谢主要结局的影响。在此，我们报告了完成试验的参与者（22 名有氧运动组、22 名饮食组、23 名有氧运动+饮食组、18 名无干预组）的试验的第三个主要结果——肠道微生物群组成。我们表明，有氧运动和饮食干预相结合与多样化和稳定的关键类群相关，而单独的运动和饮食干预则增加了类群之间的网络连接性和稳健性。干预措施没有观察到不良反应。此外，在探索性临时分析中，我们发现，当使用差异改变的肠道微生物扩增子序列变体丰度对反应者和低反应/无反应者进行分类时，并非所有受试者都以类似的方式对干预做出反应。基线时的个性化肠道微生物网络可以预测肝脏脂肪对运动干预的个体反应。我们的研究结果提出了一种基于宿主-肠道微生物生态系统相互作用来开发治疗 NAFLD 的个性化干预策略的途径，然而，未来需要大样本量的研究来验证这些发现。试用注册号为 ISRCTN 42622771。
Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise,n= 29; Diet,n= 28; Aerobic exercise + Diet,n= 29; No intervention,n= 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.
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影响因子：
16.6
作者：
Lee G;You HJ;Bajaj JS;Joo SK;Yu J;Park S;Kang H;Park JH;Kim JH;Lee DH;Lee S;Kim W;Ko G
通讯作者：
Ko G
使用样本特定网络对疾病进行个性化表征
影响因子：
14.9
作者：
Liu X;Wang Y;Ji H;Aihara K;Chen L
通讯作者：
Chen L
影响因子：
13.6
作者：
Kim HJ;Kim H;Kim JJ;Myeong NR;Kim T;Park T;Kim E;Choi JY;Lee J;An S;Sul WJ
通讯作者：
Sul WJ
影响因子：
29.4
作者：
Betrapally NS;Gillevet PM;Bajaj JS
通讯作者：
Bajaj JS
有氧运动和饮食对患有非酒精性脂肪肝的糖尿病前期患者肝脏脂肪的影响：一项随机对照试验
影响因子：
4.6
作者：
Cheng S;Ge J;Zhao C;Le S;Yang Y;Ke D;Wu N;Tan X;Zhang X;Du X;Sun J;Wang R;Shi Y;Borra RJH;Parkkola R;Wiklund P;Lu D
通讯作者：
Lu D