In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.
In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.
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DOI：
10.1192/j.eurpsy.2023.4
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发表时间：
2023-01-24
影响因子：
7.8
通讯作者：
Parsey, Ramin V. V.
中科院分区：
文献类型：
--
作者：
Bartlett, Elizabeth A. A.;Yttredahl, Ashley A. A.;Boldrini, Maura;Tyrer, Andrea E. E.;Hill, Kathryn R. R.;Ananth, Mala R. R.;Milak, Matthew S. S.;Oquendo, Maria A. A.;Mann, J. John;DeLorenzo, Christine;Parsey, Ramin V. V.
报告的童年逆境（CA）与成年后抑郁症的发展有关，并预测更严重的疾病过程。尽管5-羟色胺1A受体（5-HT 1AR）结合电位升高，特别是在中缝核中，已被证明是与重度抑郁症相关的一种特征，但我们没有在使用部分激动剂正电子发射断层扫描示踪剂[11 C] TBI-101的独立样本中复制这一发现。有证据表明，CA可以诱导5-HT 1AR表达的长期变化，因此，CA的历史可以解释不同的结果。在我们最初的报告之后，28名未服药的抑郁症患者（双相型n = 16，单极型n = 12）和19名非抑郁症健康志愿者（HV）接受了[11 C]碘化银-101成像，以量化5-HT 1AR结合潜力。抑郁发作的参与者通过童年创伤问卷分为轻度/中度和重度CA组。我们假设与轻度/中度CA和HV相比，重度CA的海马和中缝核5-HT 1AR更高。当考虑HV、抑郁发作轻度/中度CA和抑郁发作重度CA组时，存在逐区域效应（p = 0.011），这是由重度CA抑郁发作参与者的海马5-HT 1AR结合电位显著高于HV（p = 0.019）驱动的。与我们的假设相反，在中缝核中没有检测到显著的结合电位差异（p值> 0.05）。随着在更大样本中的复制，海马5-HT 1AR结合电位升高可能作为一个有前途的生物标志物，通过它来调查CA和抑郁症之间的神经生物学联系。
Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT1AR) binding potential, especially in the raphe nuclei, has been shown to be a trait associated with major depression, we did not replicate this finding in an independent sample using the partial agonist positron emission tomography tracer [11C]CUMI-101. Evidence suggests that CA can induce long-lasting changes in expression of 5-HT1AR, and thus, a history of CA may explain the disparate findings. Following up on our initial report, 28 unmedicated participants in a current depressive episode (bipolar n = 16, unipolar n = 12) and 19 non-depressed healthy volunteers (HVs) underwent [11C]CUMI-101 imaging to quantify 5-HT1AR binding potential. Participants in a depressive episode were stratified into mild/moderate and severe CA groups via the Childhood Trauma Questionnaire. We hypothesized higher hippocampal and raphe nuclei 5-HT1AR with severe CA compared with mild/moderate CA and HVs. There was a group-by-region effect (p = 0.011) when considering HV, depressive episode mild/moderate CA, and depressive episode severe CA groups, driven by significantly higher hippocampal 5-HT1AR binding potential in participants in a depressive episode with severe CA relative to HVs (p = 0.019). Contrary to our hypothesis, no significant binding potential differences were detected in the raphe nuclei (p -value s > 0.05). With replication in larger samples, elevated hippocampal 5-HT1AR binding potential may serve as a promising biomarker through which to investigate the neurobiological link between CA and depression.
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影响因子：
6.8
作者：
Harrison EL;Baune BT
通讯作者：
Baune BT
DOI：
10.1093/ijnp/pyac001
发表时间：
2022-08-04
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3
作者：
Albert PR;Vahid-Ansari F;Luckhart C
通讯作者：
Luckhart C
影响因子：
4.8
作者：
Iscan Z;Jin TB;Kendrick A;Szeglin B;Lu H;Trivedi M;Fava M;McGrath PJ;Weissman M;Kurian BT;Adams P;Weyandt S;Toups M;Carmody T;McInnis M;Cusin C;Cooper C;Oquendo MA;Parsey RV;DeLorenzo C
通讯作者：
DeLorenzo C
影响因子：
11
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
通讯作者：
Martin NG