Hierarchical Elemental Odor Coding for Fine Discrimination Between Enantiomer Odors or Cancer-Characteristic Odors.
Hierarchical Elemental Odor Coding for Fine Discrimination Between Enantiomer Odors or Cancer-Characteristic Odors.
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DOI：
10.3389/fnbeh.2022.849864
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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气味会引发各种情绪反应，比如对捕食者气味的恐惧，对疾病或癌症气味的厌恶，对男性/女性气味的吸引，以及对美味食物气味的食欲行为。然而，气味信息处理的精细气味识别仍然是难以解决的问题。嗅觉和色觉具有共同的特点，即G蛋白偶联受体是遥感器。由于不同的橙色可以通过不同的元素色（如黄色和红色）的强度比来区分，因此气味很可能被视为多层次的元素气味，元素气味的强度按优势顺序排列。例如，在玫瑰和狐狸特有的捕食者气味的混合物中，强烈的玫瑰气味减轻了老鼠对捕食者气味的恐惧。此外，尽管尿液样本中的潜血气味强于膀胱癌特征气味，但嗅探小鼠可以区分潜血阳性尿液样本中的膀胱癌气味。在对映体对映体或身体气味对癌症引起的身体气味障碍的强迫选择气味辨别任务中，嗅探小鼠在广泛的浓度范围内辨别学习嗅觉线索，随着感知模糊性的增加，正确选择率在Fechner定律中下降。在这篇综述中，我们总结了当前关于嗅觉系统如何编码和分层解码多种元素气味以控制气味驱动行为的知识。
Odors trigger various emotional responses such as fear of predator odors, aversion to disease or cancer odors, attraction to male/female odors, and appetitive behavior to delicious food odors. Odor information processing for fine odor discrimination, however, has remained difficult to address. The olfaction and color vision share common features that G protein-coupled receptors are the remote sensors. As different orange colors can be discriminated by distinct intensity ratios of elemental colors, such as yellow and red, odors are likely perceived as multiple elemental odors hierarchically that the intensities of elemental odors are in order of dominance. For example, in a mixture of rose and fox-unique predator odors, robust rose odor alleviates the fear of mice to predator odors. Moreover, although occult blood odor is stronger than bladder cancer-characteristic odor in urine samples, sniffer mice can discriminate bladder cancer odor in occult blood-positive urine samples. In forced-choice odor discrimination tasks for pairs of enantiomers or pairs of body odors vs. cancer-induced body odor disorders, sniffer mice discriminated against learned olfactory cues in a wide range of concentrations, where correct choice rates decreased in the Fechner's law, as perceptual ambiguity increased. In this mini-review, we summarize the current knowledge of how the olfactory system encodes and hierarchically decodes multiple elemental odors to control odor-driven behaviors.
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影响因子：
4.6
作者：
Gervasi SS;Opiekun M;Martin T;Beauchamp GK;Kimball BA
通讯作者：
Kimball BA
DOI：
10.1523/jneurosci.0154-12.2012
发表时间：
2012-06-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
通讯作者：
Mori K
影响因子：
64.5
作者：
Mombaerts, P;Wang, F;Axel, R
通讯作者：
Axel, R
影响因子：
64.5
作者：
Malnic, B;Hirono, J;Buck, LB
通讯作者：
Buck, LB
影响因子：
64.8
作者：
Niessing, Joern;Friedrich, Rainer W.
通讯作者：
Friedrich, Rainer W.