Nasopharyngeal carriage of Streptococcus pneumonia in pneumonia-prone age groups in Semarang, Java Island, Indonesia.
Nasopharyngeal carriage of Streptococcus pneumonia in pneumonia-prone age groups in Semarang, Java Island, Indonesia.
复制标题
DOI：
10.1371/journal.pone.0087431
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Verbrugh HA
中科院分区：
文献类型：
--
作者：
Farida H;Severin JA;Gasem MH;Keuter M;Wahyono H;van den Broek P;Hermans PW;Verbrugh HA
肺炎链球菌是一种世界范围内普遍存在的病原体，肺炎链球菌的鼻咽携带先于肺炎和其他肺炎球菌疾病。印度尼西亚对肺炎链球菌携带情况知之甚少，这使控制肺炎球菌疾病的策略复杂化。我们在印度尼西亚三宝垄调查了肺炎链球菌的鼻咽携带。在印度尼西亚三宝垄进行了一项基于人口的调查。对496名健康幼儿（6-60个月）和45-70岁成人进行鼻咽拭子和问卷调查。43%的6-60个月的儿童和11%的45-75岁的成年人携带肺炎链球菌。携带的决定因素为儿童（OR 7.7; 95% CI = 4.5-13.0）、被动吸烟（OR 2.1; 95% CI = 1.3-3.4）和在家接触幼儿（OR 3.0; 95% CI = 1.9-4.7）。最常见的血清型是6A/B和15B/C。目前市售疫苗覆盖儿童血清型不足50%。24%的肺炎链球菌对青霉素不敏感，45%对复方新恶唑耐药。针对这一人群中发现的血清型的市售疫苗覆盖率有限，以及对青霉素和复方新恶唑不敏感的比例很高，这表明需要针对特定区域的信息和战略来控制肺炎链球菌。
Streptococcus pneumoniae is a worldwide occurring pathogen Nasopharyngeal carriage of Streptococcus pneumoniae precedes pneumonia and other pneumococcal diseases in the community. Little is known about S. pneumoniae carriage in Indonesia, complicating strategies to control pneumococcal diseases. We investigated nasopharyngeal carriage of S. pneumoniae in Semarang, Indonesia. A population-based survey was performed in Semarang, Indonesia. Nasopharyngeal swabs and questionnaires were taken from 496 healthy young (6–60 month-old) children and 45–70 year-old adults. Forty-three percent of children aged 6–60 months and 11% of adults aged 45–75 years carried S. pneumoniae. Determinants of carriage were being a child (OR 7.7; 95% CI = 4.5–13.0), passive smoking (OR 2.1; 95% CI = 1.3–3.4), and contact with toddler(s) at home (OR 3.0; 95% CI = 1.9–4.7). The most frequent serotypes found were 6A/B and 15B/C. The current commercially available vaccines cover <50% serotypes found in children. Twenty-four percent of S. pneumoniae strains were penicillin non-susceptible, and 45% were resistant to cotrimoxazol. The limited coverage of commercially available vaccines against the serotypes found in this population, and the high proportion of non-susceptibility to penicillin and cotrimoxazol suggest the need for region-specific information and strategies to control S. pneumoniae.
登录
查看更多内容
影响因子：
3
作者：
Cardozo, Dea M.;Nascimento-Carvalho, Cristiana M.;Brandileone, Maria-Cristina C.
通讯作者：
Brandileone, Maria-Cristina C.
影响因子：
11.8
作者：
Hill, Philip C.;Townend, John;Adegbola, Richard A.
通讯作者：
Adegbola, Richard A.
影响因子：
11.8
作者：
Soewignjo, S;Gessner, BD;Arjoso, S
通讯作者：
Arjoso, S
影响因子：
6.4
作者：
Rudolph, KM;Parkinson, AJ;Butler, JC
通讯作者：
Butler, JC
DOI：
10.1016/j.ijporl.2011.08.021
发表时间：
2011-12-01
影响因子：
1.5
作者：
Korona-Glowniak, Izabela;Niedzielski, Artur;Malm, Anna
通讯作者：
Malm, Anna