Development and application of ribonucleic acid therapy strategies against COVID-19.
Development and application of ribonucleic acid therapy strategies against COVID-19.
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COVID-19核糖核酸治疗策略的开发和应用
DOI：
10.7150/ijbs.72706
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发表时间：
2022
影响因子：
9.2
通讯作者：
Huang, Jian
中科院分区：
文献类型：
--
作者：
Ning, Lin;Liu, Mujiexin;Gou, Yushu;Yang, Yue;He, Bifang;Huang, Jian
2019冠状病毒病（COVID-19）大流行由严重急性呼吸系统综合征2型冠状病毒（SARS-CoV-2）引起，自爆发以来至今仍是全球健康危机。先进的生物技术和研究结果已经揭示了许多合适的病毒和宿主靶点，用于广泛的治疗策略。新兴的核糖核酸治疗可以通过基于沃森-克里克碱基配对的转录后基因沉默（PTGS）来调节基因表达。RNA疗法，包括反义寡核苷酸（阿索）、核酶、RNA干扰（RNAi）、适体等，用于治疗基因组与SARV-CoV-2相似的SARS-CoV，过去的经验也适用于COVID-19的治疗。目前已有多项基于RNA治疗策略的SARS-CoV-2研究报道，全球有十几项相关的临床前或临床试验正在进行中。RNA治疗一直是COVID-19治疗中非常活跃和重要的一部分。本文综述了核糖核酸治疗策略的发展和应用，讨论了相应的问题和挑战，并提出了新的策略和解决方案。
The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2), remaining a global health crisis since its outbreak until now. Advanced biotechnology and research findings have revealed many suitable viral and host targets for a wide range of therapeutic strategies. The emerging ribonucleic acid therapy can modulate gene expression by post-transcriptional gene silencing (PTGS) based on Watson-Crick base pairing. RNA therapies, including antisense oligonucleotides (ASO), ribozymes, RNA interference (RNAi), aptamers, etc., were used to treat SARS-CoV whose genome is similar to SARV-CoV-2, and the past experience also applies for the treatment of COVID-19. Several studies against SARS-CoV-2 based on RNA therapeutic strategy have been reported, and a dozen of relevant preclinical or clinical trials are in process globally. RNA therapy has been a very active and important part of COVID-19 treatment. In this review, we focus on the progress of ribonucleic acid therapeutic strategies development and application, discuss corresponding problems and challenges, and suggest new strategies and solutions.
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