Early generalized overgrowth in autism spectrum disorder: prevalence rates, gender effects, and clinical outcomes.
Early generalized overgrowth in autism spectrum disorder: prevalence rates, gender effects, and clinical outcomes.
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DOI：
10.1016/j.jaac.2014.07.008
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发表时间：
2014-10
影响因子：
13.3
通讯作者：
Chawarska, Katarzyna
中科院分区：
文献类型：
--
作者：
Campbell, Daniel J.;Chang, Joseph;Chawarska, Katarzyna
虽然早期的头部和身体过度生长在自闭症谱系障碍（ASD）中已经有很好的记录，但其患病率和意义仍不清楚。目前还不清楚过度生长对男性和女性的影响是否不同，以及它是否与以后的临床结果有关。为了评估躯体过度生长的患病率、性别影响以及与临床结局的相关性，回顾性收集了ASD幼儿（n=200）和典型发育（TD; n=147）社区对照组出生至2岁之间的头围、身高和体重测量值。在4年时评估症状严重程度、语言和非语言功能。ASD患儿的生长发育异常与早期全身性过度生长（EGO）相一致。与社区对照组相比，患有ASD的男孩（而不是女孩）更大，并且表现出极端EGO的比例增加（18.0%对3.4%）。出生时较大的身体和出生后过度生长与4岁时较差的社交、语言和非语言技能独立相关。虽然ASD的早期生长异常比以前认为的要少见，但它们的存在预示着4岁时社交、语言和非语言技能较低，这表明它们可能构成识别ASD幼儿的生物标志物，这些幼儿可能面临不太理想的结局。研究结果强调，寻找ASD非典型脑发育的潜在机制应考虑产前和产后早期神经和非神经组织发育的因素，并且可以通过发现早期过度生长可能更容易观察到男性比女性ASD。
Although early head and body overgrowth have been well-documented in autism spectrum disorder (ASD), their prevalence and significance remain unclear. It is also unclear whether overgrowth affects males and females differentially, and whether it is associated with clinical outcomes later in life. To evaluate prevalence of somatic overgrowth, gender effects, and associations with clinical outcomes, head circumference, height, and weight measurements were collected retrospectively between birth and 2 years of age in toddlers with ASD (n=200) and typically developing (TD; n=147) community controls. Symptom severity, verbal, and nonverbal functioning were assessed at 4 years. Abnormalities in somatic growth in infants with ASD were consistent with early generalized overgrowth (EGO). Boys but not girls with ASD were larger and exhibited an increased rate of extreme EGO compared to community controls (18.0% versus 3.4%). Presence of a larger body at birth and postnatal overgrowth were associated independently with poorer social, verbal, and nonverbal skills at 4 years. Although early growth abnormalities in ASD are less common than previously thought, their presence is predictive of lower social, verbal, and nonverbal skills at 4 years, suggesting that they may constitute a biomarker for identifying toddlers with ASD at risk for less-optimal outcomes. The results highlight that the search for mechanisms underlying atypical brain development in ASD should consider factors responsible for both neural and non-neural tissue development during prenatal and early postnatal periods, and can be informed by the finding that early overgrowth may be more readily observed in males than females with ASD.
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影响因子：
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作者：
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通讯作者：
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DOI：
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DOI：
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发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
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作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team