Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.
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DOI：
10.4049/jimmunol.1301777
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发表时间：
2014-02-15
期刊：
影响因子：
--
通讯作者：
Abbas AK
中科院分区：
文献类型：
--
作者：
Gratz IK;Rosenblum MD;Maurano MM;Paw JS;Truong HA;Marshak-Rothstein A;Abbas AK
Immune homeostasis in peripheral tissues is achieved by maintaining a balance between pathogenic effector T cells (Teff) and protective Foxp3+ regulatory T cells (Treg). Using a mouse model of an inducible tissue-antigen we demonstrate that antigen (Ag) persistence is a major determinant of the relative frequencies of Teff and Treg cells. Encounter of transferred naïve CD4+ T cells with transiently expressed tissue-Ag leads to generation of cytokine-producing Teff cells and peripheral Treg cells. Persistent expression of Ag, a mimic of self Ag, leads to functional inactivation and loss of the Teff cells with preservation of Treg in the target tissue. The inactivation of Teff cells by persistent Ag is associated with reduced ERK phosphorylation (pERK), whereas Treg cells show less reduction in pERK and are relatively resistant to ERK inhibition. Our studies reveal a crucial role for Ag in maintaining appropriate ratios of Ag-specific Teff to Treg cells in tissues.
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影响因子：
64.8
作者：
Rosenblum, Michael D.;Gratz, Iris K.;Paw, Jonathan S.;Lee, Karen;Marshak-Rothstein, Ann;Abbas, Abul K.
通讯作者：
Abbas, Abul K.
影响因子：
17.1
作者：
Rosenblum MD;Gratz IK;Paw JS;Abbas AK
通讯作者：
Abbas AK
影响因子：
64.8
作者：
MOMBAERTS, P;CLARKE, AR;TONEGAWA, S
通讯作者：
TONEGAWA, S
影响因子：
29.7
作者：
Josefowicz SZ;Lu LF;Rudensky AY
通讯作者：
Rudensky AY
DOI：
10.1073/pnas.0806289106
发表时间：
2008-12-23
影响因子：
11.1
作者：
Leignadier, Julie;Hardy, Marie-Pierre;Labrecque, Nathalie
通讯作者：
Labrecque, Nathalie