Impairment of pulmonary function is an independent risk factor for atrial fibrillation: the Takahata study.
Impairment of pulmonary function is an independent risk factor for atrial fibrillation: the Takahata study.
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DOI：
10.7150/ijms.8.514
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发表时间：
2011
影响因子：
3.6
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Shibata Y;Watanabe T;Osaka D;Abe S;Inoue S;Tokairin Y;Igarashi A;Yamauchi K;Kimura T;Kishi H;Aida Y;Nunomiya K;Nemoto T;Sato M;Konta T;Kawata S;Kato T;Kayama T;Kubota I
背景资料：慢性肺病，如慢性阻塞性肺病（COPD）和纤维化肺病，以及心房纤颤（AF），在老年人中普遍存在。肺功能受损的老年人心脏合并症的影响不容忽视，因为它们会影响死亡率。房颤患病率与肺功能之间的关系尚不清楚。本研究的目的是评估这种关系的参与者在健康检查。研究方法：本研究纳入了2004年至2005年在日本高田市参加基于社区的年度健康检查的40岁或以上受试者（n = 2，917）。我们对这些受试者进行了血压测量、血液采样、心电图和肺功能测定。结果：房颤组的平均FEV1%预测值和FVC %预测值显著低于非房颤组。有气流受限或肺受限的受试者中AF的患病率高于无气流受限或肺受限的受试者。此外，重度气流阻塞受试者（FEV1%预测值< 50）的AF患病率高于轻度或中度气流阻塞受试者（FEV1%预测值≥ 50），尽管70≤ FVC %预测值<80肺限制受试者和FVC %预测值<70受试者的AF患病率无差异。多元Logistic回归分析显示FEV1%预测值和FVC %预测值是AF的独立危险因素（与年龄、性别、左心室肥厚和血清B型利钠肽水平无关）。结论：肺功能受损是日本普通人群中AF的独立危险因素。
Background: Chronic pulmonary disorders, such as chronic obstructive pulmonary disease (COPD) and fibrosing lung diseases, and atrial fibrillation (AF), are prevalent in elderly people. The impact of cardiac co-morbidities in the elderly, where pulmonary function is impaired, cannot be ignored as they influence mortality. The relationship between the prevalence of AF and pulmonary function is unclear. The aim of this study was to evaluate this relationship in participants in a health check. Methods: Subjects aged 40 or older (n = 2,917) who participated in a community-based annual health check in Takahata, Japan, from 2004 through to 2005, were enrolled in the study. We performed blood pressure measurements, blood sampling, electrocardiograms, and spirometry on these subjects. Results: The mean FEV1 % predicted and FVC % predicted in AF subjects was significantly lower than in non-AF subjects. The prevalence of AF was higher in those subjects with airflow limitation or lung restriction than in those without. Furthermore, AF prevalence was higher in those subjects with severe airflow obstruction (FEV1 %predicted < 50) than in those who had mild or moderate airflow obstruction (FEV1 %predicted ≥ 50), although there was no difference between the prevalence of AF in subjects with 70≤ FVC %predicted <80 lung restriction and those with FVC %predicted <70. Multiple logistic regression analysis revealed that FEV1 %predicted and FVC %predicted are independent risk factors for AF (independent of age, gender, left ventricular hypertrophy, and serum levels of B-type natriuretic peptide). Conclusion: Impaired pulmonary function is an independent risk factor for AF in the Japanese general population.
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影响因子：
2.9
作者：
Kang H;Bae BS;Kim JH;Jang HS;Lee BR;Jung BC
通讯作者：
Jung BC
影响因子：
1.2
作者：
Inoue, Yuzuru;Kawayama, Tomotaka;Aizawa, Hisamichi
通讯作者：
Aizawa, Hisamichi
影响因子：
8.8
作者：
Amar, D;Zhang, H;Kadish, AH
通讯作者：
Kadish, AH
影响因子：
37.8
作者：
Chung, MK;Martin, DO;Van Wagoner, DR
通讯作者：
Van Wagoner, DR
影响因子：
4.8
作者：
Hsieh, BP;Pham, MX;Froelicher, VF
通讯作者：
Froelicher, VF