Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
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DOI：
10.1038/s41593-017-0007-y
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发表时间：
2017-12
影响因子：
25
通讯作者：
Drew PJ
中科院分区：
文献类型：
--
作者：
Winder AT;Echagarruga C;Zhang Q;Drew PJ
在没有任务或明显刺激的情况下，血液动力学信号的自发波动被用来推断神经活动。我们测试了这种耦合，同时测量神经活动和脑血容量（CBV）的变化在清醒的体感皮层，头部固定的小鼠在真正的休息期间，并在胡须刺激和意志搅拌。在这里，我们表明，神经血管耦合是相似的状态，和大的自发CBV的变化，在没有感觉输入的驱动下，意志胡须和身体运动。在休息期间的血流动力学信号与神经活动弱相关。CBV和血管直径的自发性波动持续当局部神经尖峰和aminamatergic输入被阻止，并在去甲肾上腺素能受体的封锁，表明自发CBV波动的非神经元起源。自发血流动力学信号反映了行为、局部神经活动和肺非神经过程的组合。
Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest, and during whisker stimulation and volitional whisking. Here we show that neurovascular coupling was similar across states, and large spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input was blocked, and during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
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影响因子：
6.3
作者：
Gao, Yu-Rong;Drew, Patrick J.
通讯作者：
Drew, Patrick J.
影响因子：
3.7
作者：
Guipponi, Olivier;Odouard, Soline;Ben Hamed, Suliann
通讯作者：
Ben Hamed, Suliann
影响因子：
25
作者：
通讯作者：
--
影响因子：
1.2
作者：
Drew PJ;Blinder P;Cauwenberghs G;Shih AY;Kleinfeld D
通讯作者：
Kleinfeld D
影响因子：
9.2
作者：
Goense, Jozien B. M.;Logothetis, Nikos K.
通讯作者：
Logothetis, Nikos K.