Perinatal exposure to FireMaster® 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior.
Perinatal exposure to FireMaster® 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior.
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DOI：
10.1016/j.yhbeh.2020.104853
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发表时间：
2020-11
影响因子：
3.5
通讯作者：
Patisaul HB
中科院分区：
文献类型：
--
作者：
Witchey SK;Al Samara L;Horman BM;Stapleton HM;Patisaul HB
Firemaster 550（FM 550）是一种阻燃剂（FR）混合物，已成为泡沫家具和婴儿用品等家居用品中最常用的FR之一。由于这种混合物很容易从产品中滤出，因此环境和人体组织的污染很普遍。我们和其他人之前的工作报告了啮齿动物和斑马鱼在生命早期暴露后的性别特异性行为缺陷。为了了解这些行为效应发生的机制，在这里，我们探讨了其成分对行为结果的影响，这些行为结果以前被证明是由发育FM 550暴露改变的。FM 550商用混合物由两种溴化化合物（BFR）和两种有机磷酸盐化合物（OPFR）以几乎相等的比例组成。BFR和OPFR组分的代谢差异和结构不同，但与已知的神经毒物相似。在此，我们检查了成年Wistar大鼠后代在围产期暴露（经口，母体）于溶媒、2000 μg/天FM 550、1000 μg/天BFR或1000 μg/天OPFR（从妊娠第0天至断奶）后的社会情绪行为。从出生后第65天开始，所有组的后代都进行了一系列的行为任务，包括开放领域，高架十字迷宫，大理石掩埋，社会互动测试，和运行轮。影响是暴露，性别和任务特定的，与溴化阻燃剂接触导致最一致的行为缺陷。总体而言，在所有剂量组和任务中，与雄性相比，暴露的雌性表现出更多的缺陷。这些发现有助于阐明不同类别的阻燃剂，独立和作为一种混合物，如何有助于暴露的性别特异性行为影响。
Firemaster 550 (FM550) is a flame retardant (FR) mixture which has become one of the most commonly used FRs in household items such as foam-based furniture and baby products. Because this mixture readily leaches from products, contamination of the environment and human tissues is widespread. Prior work by us and others has reported sex-specific behavioral deficits in rodents and zebrafish following early life exposure. In an effort to understand the mechanisms by which these behavioral effects occur, here we explored the effects of its constituents on behavioral outcomes previously shown to be altered by developmental FM550 exposure. The FM550 commercial mixture is composed of two brominated compounds (BFR) and two organophosphate compounds (OPFRs) at almost equivalent proportions. Both the BFR and the OPFR components are differentially metabolized and structurally distinct, but similar to known neurotoxicants. Here we examined adult Wistar rat offspring socioemotional behaviors following perinatal exposure (oral, to the Dam) to vehicle, 2000 μg/day FM550, 1000 μg/day BFR or 1000 μg/day OPFR from gestation day 0 to weaning. Beginning on postnatal day 65 offspring from all groups were subjected to a series of behavioral tasks including open field, elevated plus maze, marble burying, social interaction tests, and running wheel. Effects were exposure-, sex- and task-specific, with BFR exposure resulting in the most consistent behavioral deficits. Overall, exposed females showed more deficits compared to males across all dose groups and tasks. These findings help elucidate how different classes of flame retardants, independently and as a mixture, contribute to sex-specific behavioral effects of exposure.
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影响因子：
2.9
作者：
Burke, Nikita N.;Coppinger, Jonathan;Kelly, John
通讯作者：
Kelly, John
影响因子：
8.8
作者：
Castorina R;Bradman A;Stapleton HM;Butt C;Avery D;Harley KG;Gunier RB;Holland N;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
3.4
作者：
Doherty, Brett T.;Hoffman, Kate;Daniels, Julie L.
通讯作者：
Daniels, Julie L.
影响因子：
3.5
作者：
Belcher, Scott M.;Cookman, Clifford J.;Patisaul, Heather B.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.
影响因子：
4
作者：
Dishaw, Laura V.;Macaulay, Laura J.;Roberts, Simon C.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.