Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort.
Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort.
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DOI：
10.1016/j.chemosphere.2017.09.037
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发表时间：
2017-12
期刊：
影响因子：
8.8
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Castorina R;Bradman A;Stapleton HM;Butt C;Avery D;Harley KG;Gunier RB;Holland N;Eskenazi B
阻燃剂通常用于美国家庭的消费品中。对多溴二苯醚阻燃剂使用的限制导致替代化学品的使用增加，包括Firemaster 550®（FM 550®）和有机磷酸盐阻燃剂（PFR）：磷酸三（1，3-二氯-2-丙基）酯（TDCIPP）;磷酸三（氯丙基）酯（TCIPP）;磷酸三（2-氯乙基）酯（TCEP）;磷酸三苯酯（TPHP）。动物研究表明，PFR可能通过类似于某些有机磷农药（OP）的非胆碱能机制影响神经发育。尽管这些化合物广泛存在于家庭环境中，并且它们与神经毒性OP农药的结构相似，但对人类接触PFR及其健康影响的了解有限。我们测量了CHAMACOS出生队列研究（n=310）中孕妇的四种尿PFR代谢物，并评估了7岁儿童的神经发育。TDCIPP（BDCIPP：>75%的尿液样本中检测到双（1，3-二氯-2-丙基）磷酸盐）和TPHP（DPHP：磷酸二苯酯），72%的尿液样本中检测到FM 550®一种成分的代谢物异丙基苯基苯基磷酸盐（ip-PPP）。在调整后的回归模型（n=248）中，我们观察到DPHP每增加10倍，全量表智商和工作记忆分别下降2.9分（95%置信区间（CI）：-6.3，0.5）和3.9分（95% CI：-7.3，-0.5）。与DPHP模型相比，PFR代谢物摩尔总和模型中全量表智商和工作记忆的下降更大。这是第一项研究PFR和FM 550®暴露以及孕妇和儿童的潜在神经发育结果。需要进行更多的研究。
Flame retardants are commonly used in consumer products found in U.S. households. Restrictions on the use of polybrominated diphenyl ether flame retardants have resulted in increased use of replacement chemicals, including Firemaster 550® (FM 550®) and organophosphate flame retardants (PFRs): tris(1,3- dichloro-2-propyl) phosphate (TDCIPP); tris(chloropropyl) phosphate (TCIPP); tris(2-chloroethyl) phosphate (TCEP); and triphenyl phosphate (TPHP). Animal research suggests that PFRs may affect neurodevelopment through noncholinergic mechanisms similar to some organophosphate (OP) pesticides. Despite the widespread presence of these compounds in home environments, and their structural similarity to neurotoxic OP pesticides, understanding of human exposure and health effects of PFRs is limited. We measured four urinary PFR metabolites from pregnant women in the CHAMACOS birth cohort study (n=310) and assessed neurodevelopment of their children at age 7. Metabolites of TDCIPP (BDCIPP: bis(1,3-dichloro-2-propyl) phosphate) and TPHP (DPHP: diphenyl phosphate) were detected in >75% of urine samples, and isopropylphenyl phenyl phosphate (ip-PPP), a metabolite of one component of FM 550®, was detected in 72% of urine samples. We observed decreases of 2.9 points (95% Confidence Interval (CI): −6.3, 0.5) and 3.9 points (95% CI: −7.3,−0.5) in Full-Scale intelligence quotient and Working Memory, respectively, for each ten-fold increase in DPHP in adjusted regression models (n=248). Decreases in Full-Scale IQ and Working Memory were greater in models of the molar sum of the PFR metabolites compared to the DPHP models. This is the first study to examine PFR and FM 550® exposures and potential neurodevelopmental outcomes in pregnant women and children. Additional research is warranted.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
10.4
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影响因子：
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作者：
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影响因子：
10.4
作者：
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通讯作者：
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