DiseaseMeth version 3.0: a major expansion and update of the human disease methylation database.
DiseaseMeth version 3.0: a major expansion and update of the human disease methylation database.
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疾病eth 3.0版：人类疾病甲基化数据库的主要扩展和更新。
DOI：
10.1093/nar/gkab1088
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发表时间：
2022-01-07
影响因子：
14.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Xing J;Zhai R;Wang C;Liu H;Zeng J;Zhou D;Zhang M;Wang L;Wu Q;Gu Y;Zhang Y
DNA甲基化作为生物标志物的潜力越来越大，因为它与疾病有关。在过去的5年中，DNA甲基化数据的数量也大幅增长。为了方便访问这些碎片化数据，我们在DiseaseMeth 2.0版本的基础上提出了DiseaseMeth 3.0版本，其中包含的疾病数量从88个增加到162个，高通量图谱样本从32 701个增加到49 949个。实验证实的协会增加了448对手动文献挖掘从PubMed的1472篇论文。更新了搜索、分析和工具部分，以提高性能。特别地，FunctionSearch现在提供了来自定位的GO和KEGG注释的基因的功能富集。我们还开发了一个统一的分析管道，用于从数据库中存储的原始数据中识别差异DNA甲基化基因（DMG）。在99种疾病中检出DMG 22718个。这些DMG使用两个自主开发的在线工具提供疾病评估应用，甲基化疾病相关性和癌症预后与共甲基化。所有查询结果都可以下载，也可以根据使用的搜索部分通过箱形图，热图或网络模块显示。DiseaseMeth 3.0版可在http://diseasemeth.edbc.org/上免费获得。
DNA methylation has a growing potential for use as a biomarker because of its involvement in disease. DNA methylation data have also substantially grown in volume during the past 5 years. To facilitate access to these fragmented data, we proposed DiseaseMeth version 3.0 based on DiseaseMeth version 2.0, in which the number of diseases including increased from 88 to 162 and High-throughput profiles samples increased from 32 701 to 49 949. Experimentally confirmed associations added 448 pairs obtained by manual literature mining from 1472 papers in PubMed. The search, analyze and tools sections were updated to increase performance. In particular, the FunctionSearch now provides for the functional enrichment of genes from localized GO and KEGG annotation. We have also developed a unified analysis pipeline for identifying differentially DNA methylated genes (DMGs) from the original data stored in the database. 22 718 DMGs were found in 99 diseases. These DMGs offer application in disease evaluation using two self-developed online tools, Methylation Disease Correlation and Cancer Prognosis & Co-Methylation. All query results can be downloaded and can also be displayed through a box plot, heatmap or network module according to whichever search section is used. DiseaseMeth version 3.0 is freely available at http://diseasemeth.edbc.org/.
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影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
4.4
作者：
Bibikova, Marina;Barnes, Bret;Shen, Richard
通讯作者：
Shen, Richard
DOI：
10.1073/pnas.93.18.9821
发表时间：
1996-09-03
影响因子：
11.1
作者：
Herman, JG;Graff, JR;Baylin, SB
通讯作者：
Baylin, SB
影响因子：
14.9
作者：
Xuan Lin QX;Sian S;An O;Thieffry D;Jha S;Benoukraf T
通讯作者：
Benoukraf T
影响因子：
4.3
作者：
Liang, Shuang;Li, Zhenzhi;Wu, Lijie
通讯作者：
Wu, Lijie