High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear.
High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear.
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DOI：
10.3389/fnbeh.2021.595049
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发表时间：
2021
影响因子：
3
通讯作者：
Wiltgen BJ
中科院分区：
文献类型：
--
作者：
Graham J;D'Ambra AF;Jung SJ;Teratani-Ota Y;Vishwakarma N;Venkatesh R;Parigi A;Antzoulatos EG;Fioravante D;Wiltgen BJ
海马体可以分为不同的部分，对学习和记忆有独特的贡献。背侧海马体支持空间学习和导航等认知过程，而腹侧海马体调节与恐惧、焦虑和奖励相关的情绪行为。在当前的研究中，我们确定了腹侧CA1的锥体细胞如何在情境恐惧条件反射任务中对空间线索和厌恶刺激做出反应。我们还研究了高频和低频刺激这些神经元对防御行为的影响。与之前在海马背侧的研究类似，我们发现腹侧CA1细胞在新的空间环境下表达高水平的c-Fos。然而，令人惊讶的是，当环境与脚震配对时，激活的神经元数量并没有增加。甚至在腹侧CA1锥体细胞亚群中也是如此，这些细胞直接向杏仁核发送信号。当这些细胞在高频率（20 Hz）下受到刺激时，我们观察到基底杏仁核神经元的前馈抑制和情境恐惧的表达受损。相比之下，低频刺激（4赫兹）并没有抑制基底杏仁核的主要细胞，反而增加了恐惧泛化。在CA1背侧也报道了类似的结果。因此，尽管背侧海马和腹侧海马之间存在明显差异，但每个节段的CA1神经元似乎对情境恐惧条件反射做出了相似的贡献。
The hippocampus can be divided into distinct segments that make unique contributions to learning and memory. The dorsal segment supports cognitive processes like spatial learning and navigation while the ventral hippocampus regulates emotional behaviors related to fear, anxiety and reward. In the current study, we determined how pyramidal cells in ventral CA1 respond to spatial cues and aversive stimulation during a context fear conditioning task. We also examined the effects of high and low frequency stimulation of these neurons on defensive behavior. Similar to previous work in the dorsal hippocampus, we found that cells in ventral CA1 expressed high-levels of c-Fos in response to a novel spatial environment. Surprisingly, however, the number of activated neurons did not increase when the environment was paired with footshock. This was true even in the subpopulation of ventral CA1 pyramidal cells that send direct projections to the amygdala. When these cells were stimulated at high-frequencies (20 Hz) we observed feedforward inhibition of basal amygdala neurons and impaired expression of context fear. In contrast, low-frequency stimulation (4 Hz) did not inhibit principal cells in the basal amygdala and produced an increase in fear generalization. Similar results have been reported in dorsal CA1. Therefore, despite clear differences between the dorsal and ventral hippocampus, CA1 neurons in each segment appear to make similar contributions to context fear conditioning.
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DOI：
10.1126/science.1247485
发表时间：
2014-02-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lovett-Barron M;Kaifosh P;Kheirbek MA;Danielson N;Zaremba JD;Reardon TR;Turi GF;Hen R;Zemelman BV;Losonczy A
通讯作者：
Losonczy A
影响因子：
2.5
作者：
FRICKE, R;COWAN, WM
通讯作者：
COWAN, WM
DOI：
10.1523/jneurosci.5458-12.2013
发表时间：
2013-05-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Komorowski RW;Garcia CG;Wilson A;Hattori S;Howard MW;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
25
作者：
Karalis N;Dejean C;Chaudun F;Khoder S;Rozeske RR;Wurtz H;Bagur S;Benchenane K;Sirota A;Courtin J;Herry C
通讯作者：
Herry C