lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma.
lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma.
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lncTCF7是一种负面预后因素，敲低lncTCF7可抑制胶质瘤的迁移、增殖和致瘤性
DOI：
10.1038/s41598-017-17340-y
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发表时间：
2017-12-12
影响因子：
4.6
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Gao X;Guo X;Xue H;Qiu W;Guo X;Zhang J;Qian M;Li T;Liu Q;Shen J;Deng L;Li G
Long noncoding RNAs (lncRNAs) have been shown to play critical roles in cancer. lncTCF7 (gene symbol: WSPAR) has been reported to maintain stemness in hepatocellular carcinoma (HCC) stem cells. However, little is known about the role of lncTCF7 in glioma. The aim of this study was to identify the role of lncTCF7 in the pathogenesis of glioma. We analysed the relationship of lncTCF7 expression with clinicopathological characteristics in glioma patients. Our results showed that lncTCF7 expression was increased in glioma tissues compared with that in normal brain tissues (P 0.001). Moreover, lncTCF7 was significantly associated with WHO grade (I–II vs. III–IV; P = 0.006) and tumour size (3 cm vs. T ≥ 3 cm; P = 0.025). Meanwhile, patients with high lncTCF7 expression levels exhibited markedly worse overall survival prognoses (P 0.01). Loss of function assays revealed that knockdown of lncTCF7 significantly inhibited glioma cell migration, proliferation and tumorigenicity in vitro and in vivo. Furthermore, we found that hypoxia induced lncTCF7 expression in an autocrine manner through IL-6 in glioma. In conclusion, lncTCF7 may play a vital role in glioma progression and serves as a potential prognostic biomarker in glioma patients, providing new targets for glioma therapy.
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DOI：
10.1073/pnas.060025397
发表时间：
2000-04-11
影响因子：
11.1
作者：
Lin, SY;Xia, WY;Hung, MC
通讯作者：
Hung, MC
影响因子：
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作者：
Ostrom, Quinn T.;Bauchet, Luc;Barnholtz-Sloan, Jill S.
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Barnholtz-Sloan, Jill S.
影响因子：
9.7
作者：
Jia, Peng;Cai, Heng;Xue, Yixue
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Xue, Yixue
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10.6
作者：
Schonberg, David L.;Lubelski, Daniel;Miller, Tyler E.;Rich, Jeremy N.
通讯作者：
Rich, Jeremy N.
DOI：
10.1016/j.bbrc.2013.03.021
发表时间：
2013-04-19
影响因子：
3.1
作者：
Jin, Xiong;Jin, Xun;Kim, Hyunggee
通讯作者：
Kim, Hyunggee