Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease.
Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease.
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DOI：
10.1016/j.rmed.2012.03.006
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发表时间：
2012-07
影响因子：
4.3
通讯作者：
Swigris, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Fischer, Aryeh;Solomon, Joshua J.;du Bois, Roland M.;Deane, Kevin D.;Olson, Amy L.;Fernandez-Perez, Evans R.;Huie, Tristan J.;Stevens, Allen D.;Gill, Mary B.;Rabinovitch, Avi M.;Lynch, David A.;Burns, David A.;Pineiro, Isabel S.;Groshong, Steve D.;Achcar, Rosane D. Duarte;Brown, Kevin K.;Martin, Richard J.;Swigris, Jeffrey J.
我们试图描述一组新的肺部疾病患者，抗环瓜氨酸肽（CCP）抗体阳性，无类风湿性关节炎（RA）或其他结缔组织疾病（CTD）。研究样本包括74名有呼吸道症状的受试者，在2008年1月至2010年1月进行评估，发现抗CCP抗体阳性，但没有RA或其他CTD的证据。作为常规临床评价的一部分，每个人都接受了血清学检测、肺生理学检测和胸部高分辨率计算机断层扫描（HRCT）扫描。大多数受试者是女性，大多数是前吸烟者。确定了四种不同的放射学表型：孤立性气道疾病（54%）、孤立性间质性肺病（ILD）（14%）、混合性气道疾病和ILD（26%）以及肺纤维化合并肺气肿（7%）。该队列以气道疾病为主，无论是孤立的还是沿着常见的间质性肺炎ILD模式。在高滴度抗CCP阳性受试者（n=33）中，3例在中位随访449天期间出现RA的关节表现。我们描述了一个独特的队列患者抗CCP抗体阳性和肺部疾病，现有的RA或其他CTD的情况下。该队列的肺表型特征与已确诊的RA相似，其中一些患者在短期随访中发展为关节型RA。抗CCP抗体阳性在肺部疾病而非类风湿性关节炎患者中的意义尚不清楚，但我们认为需要进一步研究。
We sought to characterize a novel cohort of patients with lung disease, anti-cyclic citrullinated peptide (CCP) antibody positivity, without rheumatoid arthritis (RA) or other connective tissue disease (CTD). The study sample included 74 subjects with respiratory symptoms, evaluated January 2008–January 2010 and found to have a positive anti-CCP antibody but no evidence for RA or other CTD. Each underwent serologic testing, pulmonary physiology testing, and thoracic high-resolution computed tomography (HRCT) scan as part of routine clinical evaluation. The majority of subjects were women, and most were former cigarette smokers. Four distinct radiographic phenotypes were identified: isolated airways disease (54%), isolated interstitial lung disease (ILD) (14%), mixed airways disease and ILD (26%), and combined pulmonary fibrosis with emphysema (7%). This cohort had a predominance of airways disease, either in isolation or along with a usual interstitial pneumonia-pattern of ILD. Among subjects with high-titer anti-CCP positivity (n=33), three developed the articular manifestations of RA during a median follow-up of 449 days. We have described a unique cohort of patients with anti-CCP antibody positivity and lung disease in the absence of existing RA or other CTD. The lung phenotypic characteristics of this cohort resemble those of established RA and a few of these patients have developed articular RA within a short period of follow-up. The implications of a positive anti-CCP antibody among patients with lung disease but not RA are not yet known, but we believe requires further investigation.
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影响因子：
5
作者：
Lutteri, Laurence;Malaise, Michel;Chapelle, Jean-Paul
通讯作者：
Chapelle, Jean-Paul
影响因子：
3.9
作者：
Aubart, Fleur;Crestani, Bruno;Dieude, Philippe
通讯作者：
Dieude, Philippe
影响因子：
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作者：
Gizinski, Alison M.;Mascolo, Margherita;Loucks, Jennifer L.;Kervitsky, Alma;Meehan, Richard T.;Brown, Kevin K.;Holers, V. Michael;Deane, Kevin D.
通讯作者：
Deane, Kevin D.
影响因子：
15.9
作者：
Rangel-Moreno, Javier;Hartson, Louise;Randall, Troy D.
通讯作者：
Randall, Troy D.
影响因子：
2.8
作者：
Inui, Naoki;Enomoto, Noriyuki;Chida, Kingo
通讯作者：
Chida, Kingo