Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infection: a cohort study in Israeli patients.
Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infection: a cohort study in Israeli patients.
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轻度COVID-19感染的发病、持续时间和未解决的症状，包括嗅觉和味觉变化：以色列患者的队列研究
DOI：
10.1016/j.cmi.2021.02.008
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发表时间：
2021-02-16
期刊：
影响因子：
--
通讯作者：
Niv MY
中科院分区：
文献类型：
--
作者：
Klein H;Asseo K;Karni N;Benjamini Y;Nir-Paz R;Muszkat M;Israel S;Niv MY
描述2019年轻度冠状病毒病（COVID-19）患者6个月的纵向症状，以潜在地帮助疾病管理。在6个月期间（2020年4月至2020年10月），我们对以色列103名轻度COVID-19患者进行了电话访谈。患者通过社交媒体和口碑招募，并根据其未解决症状的报告接受最多4次采访。入选标准要求参与者为18岁或以上的以色列居民，COVID-19实时PCR结果呈阳性，症状不严重。分析症状的发作、持续时间、严重程度和消退情况。44%（45/103）、41%（42/103）、39%（40/103）和38%（39/103）的患者以头痛、发热、肌肉酸痛和干咳为首发症状。在发病后3.9 ± 5.4和4.6 ± 5.7天（平均值±标准差（SD））分别出现味觉和味觉变化。在流行症状中，发热持续时间最短（5.8 ± 8.6天），味觉和嗅觉变化是持续时间最长的症状（17.2 ± 17.6和18.9 ± 19.7天;持续时间在60天时删失）。嗅觉恢复的时间与嗅觉变化的程度相关。在6个月随访时，46%（47/103）的患者至少有一种未解决的症状，最常见的是疲劳（22%，23/103），嗅觉和味觉变化（分别为15%，15/103和8%，8/103）和呼吸困难（8%，8/103）。轻度COVID-19的长期影响表现在近一半的参与者在6个月后报告至少一个未解决的症状。
To characterize longitudinal symptoms of mild coronavirus disease 2019 (COVID-19) patients for a period of 6 months, to potentially aid in disease management. Phone interviews were conducted with 103 patients with mild COVID-19 in Israel over a 6-month period (April 2020 to October 2020). Patients were recruited via social media and word to mouth and were interviewed up to 4 times, depending on reports of their unresolved symptoms. Inclusion criteria required participants to be residents of Israel aged 18 years or older, with positive COVID-19 real-time PCR results and nonsevere symptoms. The onset, duration, severity and resolution of symptoms were analysed. A total of 44% (45/103), 41% (42/103), 39% (40/103) and 38% (39/103) of patients experienced headache, fever, muscle ache and dry cough as the first symptom respectively. Smell and taste changes were experienced at 3.9 ± 5.4 and 4.6 ± 5.7 days (mean ± standard deviation (SD)) after disease onset respectively. Among prevalent symptoms, fever had the shortest duration (5.8 ± 8.6 days), and taste and smell changes were the longest-lasting symptoms (17.2 ± 17.6 and 18.9 ± 19.7 days; durations censored at 60 days). Longer recovery of the sense of smell correlated with the extent of smell change. At the 6-month follow-up, 46% (47/103) of the patients had at least one unresolved symptom, most commonly fatigue (22%, 23/103), smell and taste changes (15%, 15/103 and 8%, 8/103 respectively) and breathing difficulties (8%, 8/103). Long-lasting effects of mild COVID-19 manifested in almost half of the participants reporting at least one unresolved symptom after 6 months.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.4
作者：
Speth, Marlene M.;Singer-Cornelius, Thirza;Sedaghat, Ahmad R.
通讯作者：
Sedaghat, Ahmad R.
影响因子：
2.6
作者：
Gorzkowski, Victor;Bevilacqua, Sibylle;Duc Trung Nguyen
通讯作者：
Duc Trung Nguyen
隔离设施中的COVID-19患者嗅觉和味道功能障碍的趋势。
影响因子：
4.5
作者：
Seo MY;Seok H;Hwang SJ;Choi HK;Jeon JH;Sohn JW;Park DW;Lee SH;Choi WS
通讯作者：
Choi WS
影响因子：
3.3
作者：
Jalessi, Maryam;Barati, Mitra;Farhadi, Mohammad
通讯作者：
Farhadi, Mohammad