Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: is there a role in tolerance induction?
Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: is there a role in tolerance induction?
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DOI：
10.1111/pai.12143
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Sampson HA
中科院分区：
文献类型：
--
作者：
Konstantinou GN;Nowak-Węgrzyn A;Bencharitiwong R;Bardina L;Sicherer SH;Sampson HA
在横断面病例对照研究中，血清食物特异性伊加抗体降低与过敏性疾病相关。本研究的目的是前瞻性地比较鸡蛋过敏儿童和鸡蛋耐受儿童的蛋清特异性IgA和IgA 2水平。对17名鸡蛋过敏儿童进行了前瞻性随访。用灵敏的ELISA法测定其血清中的总伊加、EW特异性伊加和EW特异性IgA_2水平。作为阴性对照，使用先前没有鸡蛋过敏史的儿童。鸡蛋过敏的儿童或没有伴随牛奶过敏作为额外的控制与酪蛋白特异性伊加的测量进行了评估。经过2.5±0.9年的治疗，17例过敏儿童中有9例对烤鸡蛋耐受，8例仍对烤鸡蛋过敏。与阴性对照组（99.4ng/ml）相比，鸡蛋过敏组受试者的基线EW特异性IgA 2水平（中位数23.9ng/ml）显著较低，在研究期间，9名对烤鸡蛋耐受的过敏儿童中有8名儿童的EW特异性IgA 2水平显著升高28%。在任何研究组中，EW特异性伊加均未随时间发生显著变化。伴鸡蛋过敏的非牛奶过敏受试者的酪蛋白特异性伊加水平几乎是牛奶和鸡蛋过敏受试者的3倍（P=0.025）。这些结果表明，过敏原特异性IgA 2抗体在诱导食物耐受性的潜在作用。此外，他们支持这样的假设，即过敏原特异性IgA 2的不成熟或受损的产生可能与食物过敏的病理生理学有关，这是一种似乎对罪魁祸首过敏原具有选择性的缺陷。
Decreased serum food-specific-IgA antibodies have been associated with allergic disease in cross-sectional, case-control studies. The purpose of this study was to prospectively compare egg-white-(EW)-specific-IgA and IgA2 levels between egg-allergic children and children tolerating egg. Seventeen egg allergic children were followed prospectively. Total IgA, EW-specific-IgA and EW-specific-IgA2 levels were measured in their sera with a sensitive ELISA. As negative controls were used children with no previous history of egg allergy. Egg-allergic children with or without concomitant milk allergy were evaluated as additional controls with measurement of casein-specific-IgA. After 2.5±0.9 years, 9 out of 17 allergic children became tolerant and 8 remained allergic to baked egg. Baseline EW-specific-IgA2 levels were significantly lower in the egg-allergic subjects (median 23.9ng/ml) compared with the negative control subjects (99.4ng/ml) and increased significantly by 28% over the study time period in 8 out of the 9 allergic children that became tolerant to baked egg. There was no significant change over time in EW-specific-IgA in any of the study groups. Non-milk-allergic subjects with concomitant egg allergy had almost 3-fold higher casein-specific-IgA levels than the milk- and egg-allergic subjects (P=0.025). These results suggest a potential role for allergen-specific-IgA2 antibodies in the induction of food tolerance. Furthermore, they support the hypothesis that immature or impaired production of allergen-specific-IgA2 may be associated with the pathophysiology of food allergy, a defect that seems to be selective for the culprit allergen.
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DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
影响因子：
15.3
作者：
Karlsson, MR;Rugtveit, J;Brandtzaeg, P
通讯作者：
Brandtzaeg, P
影响因子：
14.2
作者：
Francis, James N.;James, Louisa K.;Till, Stephen J.
通讯作者：
Till, Stephen J.
影响因子：
3.6
作者：
Noma, T;Yamaguchi, K;Baba, M
通讯作者：
Baba, M
影响因子：
5.4
作者：
Jutel, M;Akdis, M;Akdis, CA
通讯作者：
Akdis, CA