Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
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DOI：
10.1016/j.cyto.2009.02.003
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发表时间：
2009-05
期刊：
影响因子：
3.8
通讯作者：
Schwartz, Ann G.
中科院分区：
文献类型：
--
作者：
Van Dyke, Alison L.;Cote, Michele L.;Wenzlaff, Angie S.;Land, Susan;Schwartz, Ann G.
炎症在慢性疾病中的作用正在被考虑。以前的研究已经检查了一些关键炎症基因中的SNP，并包括少数非裔美国人参与者。炎症通路SNP频率的变化可能有助于解释疾病风险的种族差异。通过对103名非裔美国人和380名高加索人无关的健康女性进行基于人群的研究，我们研究了70种细胞因子和细胞因子受体SNP的种族和等位基因频率之间的关系。分析了基因型和单倍型频率与种族之间的关系。符合分析标准的70个SNPs中有52个的等位基因频率在种族间存在显著差异。在32个促炎性和20个抗炎性SNP中，其等位基因频率因种族而显著变化，高加索人和非洲裔美国人之间的促炎性SNP和抗炎性SNP的变体等位基因频率差异分别在6%-37%和7%-53%之间。我们的研究结果表明，虽然等位基因频率确实因种族而异，但种族群体并不能简单地由促炎或抗炎基因谱来代表。考虑到炎症基因SNPs等位基因频率的种族差异，研究这些SNPs与疾病之间的关联的研究至少应该在他们的分析中纳入自我报告的种族。
The role of inflammation is being considered in chronic diseases. Previous studies have examined SNPs in a few key inflammatory genes and have included small numbers of African American participants. Variation in the frequencies of inflammatory pathway SNPs may help to explain racial disparities in disease risk. Through a population-based study of 103 African American and 380 Caucasian unrelated, healthy women, we examined the relationships between race and allele frequencies of 70 cytokine and cytokine receptor SNPs. The associations between genotypic and haplotype frequencies and race were also analyzed. Allelic frequencies for 52 out of the 70 SNPs meeting criteria for analysis differed significantly by race. Of the 32 pro-inflammatory and 20 anti-inflammatory SNPs for which the allele frequencies varied significantly by race, variant allele frequency differences between Caucasians and African Americans ranged between 6%–37% and 7%–53% for pro-inflammatory SNPs and anti-inflammatory SNPs, respectively. Our findings suggest that while allele frequencies do vary by race, racial groups are not simplistically represented by a pro-inflammatory or anti-inflammatory genetic profile. Given the racial variability in allele frequencies in inflammatory gene SNPs, studies examining the association between these SNPs and disease should at least incorporate self-reported race in their analyses.
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