Epidemiology of esophageal cancer in Japan and China.
Epidemiology of esophageal cancer in Japan and China.
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DOI：
10.2188/jea.je20120162
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发表时间：
2013
影响因子：
4.7
通讯作者：
Tanaka H
中科院分区：
文献类型：
--
作者：
Lin Y;Totsuka Y;He Y;Kikuchi S;Qiao Y;Ueda J;Wei W;Inoue M;Tanaka H
为了准备食管癌发病机制的多学科合作研究，作者回顾了已发表的文献，以确定日本和中国在食管癌流行病学方面的相似性和差异。食管鳞状细胞癌（ESCC）是主要的组织学类型，而食管腺癌的发病率在这两个国家仍然非常低。在这两个国家的大量流行病学研究表明，饮酒和吸烟是ESCC的危险因素。然而，日本和中国在食管癌的许多方面存在差异，包括癌症负担，发病率和死亡率模式，死亡率的性别比，危险因素谱和遗传变异。中国的总体发病率和死亡率高于日本，死亡率和发病模式的变化在中国大于日本。在研究期间（1987-2000年），中国年龄调整死亡率的下降比日本更明显。中国高发病率和低发病率地区的风险因素概况不同，但在日本则无差异。吸烟和饮酒与ESCC风险的关联在中国似乎比日本弱。中国的全基因组关联研究表明，几个染色体区域的变异会增加风险，但在日本，只有酒精代谢基因的遗传变异与ESCC风险显著相关。需要一个设计良好的多学科流行病学研究来检查饮食和饮食习惯在ESCC风险中的作用。
In preparation for a collaborative multidisciplinary study of the pathogenesis of esophageal cancer, the authors reviewed the published literature to identify similarities and differences between Japan and China in esophageal cancer epidemiology. Esophageal squamous cell carcinoma (ESCC) is the predominant histologic type, while the incidence of esophageal adenocarcinoma remains extremely low in both countries. Numerous epidemiologic studies in both countries show that alcohol consumption and cigarette smoking are contributing risk factors for ESCC. There are differences, however, in many aspects of esophageal cancer between Japan and China, including cancer burden, patterns of incidence and mortality, sex ratio of mortality, risk factor profiles, and genetic variants. Overall incidence and mortality rates are higher in China than in Japan, and variation in mortality and incidence patterns is greater in China than in Japan. During the study period (1987–2000), the decline in age-adjusted mortality rates was more apparent in China than in Japan. Risk factor profiles differed between high- and low-incidence areas within China, but not in Japan. The association of smoking and drinking with ESCC risk appears to be weaker in China than in Japan. Genome-wide association studies in China showed that variants in several chromosome regions conferred increased risk, but only genetic variants in alcohol-metabolizing genes were significantly associated with ESCC risk in Japan. A well-designed multidisciplinary epidemiologic study is needed to examine the role of diet and eating habits in ESCC risk.
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影响因子：
3.8
作者：
Gao Y;Hu N;Han X;Giffen C;Ding T;Goldstein A;Taylor P
通讯作者：
Taylor P
影响因子：
29.4
作者：
Cui, Ri;Kamatani, Yoichiro;Matsuda, Koichi
通讯作者：
Matsuda, Koichi
DOI：
10.1093/jnci/djn211
发表时间：
2008-08-20
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Brown LM;Devesa SS;Chow WH
通讯作者：
Chow WH
影响因子：
30.8
作者：
通讯作者：
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中国安阳市食管鳞状细胞癌及其癌前病变的患病率和危险因素：基于人群的内镜调查。
影响因子：
8.8
作者：
通讯作者：
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