Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial.
Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial.
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DOI：
10.1002/jcsm.12775
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Itoh H
中科院分区：
文献类型：
--
作者：
Uchiyama K;Adachi K;Muraoka K;Nakayama T;Oshida T;Yasuda M;Hishikawa A;Minakuchi H;Miyashita K;Tokuyama H;Wakino S;Itoh H
有氧和阻力训练对严重慢性肾脏疾病（CKD）患者的潜在影响尚未完全阐明。本研究调查了基于家庭的运动计划对4期CKD患者身体功能和健康相关生活质量（HRQOL）的影响，相当于肾小球滤过率估计为15-30 mL/min/1.73 m2。46例4期CKD患者（中位年龄73岁，男性33例）被随机分为运动组（n = 23）和对照组（n = 23）。运动组患者每周在家进行3次有氧运动，峰值心率为40-60%，阻力训练为70%，每周2次，持续6个月。对照组患者未接受特殊干预。主要结果为渐进式穿梭行走试验中的距离和使用肾脏疾病短生命质量问卷评估的HRQOL。次要结局包括肾功能评估，包括尿素和肌酐清除率、尿液生物标志物以及与CKD相关的人体测量学和生化参数。与对照组相比，运动组增加穿梭行走测试的改善明显更大（39.4±54.6比- 21.3±46.1;P < 0.001）。在肾脏疾病生活质量方面，运动组与对照组在工作状态、社会交往质量和肾脏疾病成分总结结果方面的平均差异分别为12.76±5.76,P = 0.03; 5.97±2.59,P = 0.03; 4.81±1.71,P = 0.007。与对照组相比，运动组的肝型脂肪酸结合蛋白、血清C反应蛋白和酰基肉毒碱与游离肉毒碱比值的自然对数（ln）转化尿排泄明显减少，组间差异分别为- 0.579±0.217 （P = 0.008）、- 1.13±0.35 （P = 0.003）和- 0。058±0.024 （P = 0.01）。我们为期6个月的家庭运动计划改善了4期CKD患者的有氧能力和HRQOL，可能对肾功能和CKD相关参数有有益的影响。
The potential effects of aerobic and resistance training in patients with severe chronic kidney disease (CKD) are not fully elucidated. This study investigated the effects of a home‐based exercise programme on physical functioning and health‐related quality of life (HRQOL) in patients with Stage 4 CKD, equivalent to estimated glomerular filtration rate of 15–30 mL/min/1.73 m2. Forty‐six patients with Stage 4 CKD (median age, 73 years; 33 men) were randomly assigned to exercise (n = 23) and control (n = 23) groups. Exercise group patients performed aerobic exercise at 40–60% peak heart rate thrice weekly and resistance training at 70% of one‐repetition maximum twice weekly at home for 6 months. Control patients received no specific intervention. Primary outcomes were distance in incremental shuttle walking test and HRQOL assessed using the Kidney Disease Quality of Life—Short Form questionnaire. Secondary outcomes included kidney function assessed with combined urea and creatinine clearance, urinary biomarkers, and anthropometric and biochemical parameters associated with CKD. Improvement in incremental shuttle walking test was significantly greater in the exercise group compared with controls (39.4 ± 54.6 vs. −21.3 ± 46.1; P < 0.001). Among Kidney Disease Quality of Life domains, significant mean differences were observed between the exercise group and the control group in work status, quality of social interaction, and kidney disease component summary outcomes (12.76 ± 5.76, P = 0.03; 5.97 ± 2.59, P = 0.03; and 4.81 ± 1.71, P = 0.007, respectively). There were greater reductions in natural log (ln)‐transformed urinary excretion of liver‐type fatty acid‐binding protein, ln serum C‐reactive protein, and acylcarnitine to free carnitine ratio in the exercise group compared with controls, with significant between‐group differences of −0.579 ± 0.217 (P = 0.008), −1.13 ± 0.35 (P = 0.003), and −0. 058 ± 0.024 (P = 0.01), respectively. Our 6 month home‐based exercise programme improved aerobic capacity and HRQOL in patients with Stage 4 CKD, with possible beneficial effects on kidney function and CKD‐related parameters.
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影响因子：
16.2
作者：
Araki S;Haneda M;Koya D;Sugaya T;Isshiki K;Kume S;Kashiwagi A;Uzu T;Maegawa H
通讯作者：
Maegawa H
影响因子：
168.9
作者：
Matsushita, Kunihiro;van der Velde, Marije;Astor, Brad C.;Woodward, Mark;Levey, Andrew S.;de Jong, Paul E.;Coresh, Josef;Gansevoort, Ron T.
通讯作者：
Gansevoort, Ron T.
影响因子：
13.3
作者：
Almond, A.;Siddiqui, S.;Isles, C.
通讯作者：
Isles, C.
影响因子：
3.3
作者：
CHA, KC;CHERTOW, GM;WILMORE, DW
通讯作者：
WILMORE, DW
DOI：
10.1152/ajprenal.00477.2017
发表时间：
2018-04-01
影响因子：
4.2
作者：
Ohashi, Yasushi;Joki, Nobuhiko;Sakai, Ken
通讯作者：
Sakai, Ken