An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles.
An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles.
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子宫内膜厚度 8 毫米与冻融移植后 EP 风险显着增加相关 对 5,960 个妊娠周期的分析
DOI：
10.3389/fendo.2022.884553
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发表时间：
2022
影响因子：
5.2
通讯作者：
Li, Yanping
中科院分区：
文献类型：
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作者：
Zhao, Ying;Liu, Dong'e;Liu, Nenghui;Li, Yumei;Yao, Zhongyuan;Tian, Fen;Xu, Aizhuang;Li, Yanping
根据5960个妊娠冻融周期的数据，调查了最有可能诱发宫外孕的子宫内膜特征。共纳入冻融胚胎移植后妊娠周期5960个，其中宫内妊娠5777个，宫外孕183个。宫外孕是主要结局。子宫内膜厚度是主要测量变量。通过单因素分析和随后的多步logistic回归分析，最终确定宫外孕的危险因素。 1.调整混杂因素后，子宫内膜厚度可以独立预测宫外孕。子宫内膜厚度 < 8 mm、8-9.9 mm 和 10-11.9 mm 范围内的女性的调整后奇数比分别为 3.270 [95% 置信区间 (CI)，1.113-9.605，P = 0.031]、2.758（95% CI，0.987-7.707，P = 0.053）和1.456（95% CI， 与子宫内膜厚度为 12-13.9 mm 的患者相比，分别为 0.502-4.225，P = 0.489）。 2. 然而，子宫内膜类型和准备方案并未被确定为异位妊娠的危险因素。 1.冻融胚胎移植后，子宫内膜厚度<8毫米时，宫外孕的风险明显较高。 2.子宫内膜厚度薄可能与子宫内膜蠕动波异常或子宫内膜容受性异常有关。 3、对于子宫内膜厚度薄的患者，围移植期应引起足够的重视，预防EP或早期诊断。
Endometrium characteristics that are most likely to induce ectopic pregnancy were investigated on the basis of the data of 5,960 pregnant freeze-thaw cycles. A total of 5,960 pregnancy cycles after freeze-thaw embryos transfer were included, with the number of intrauterine and ectopic pregnancies being 5,777 and 183, respectively. Ectopic pregnancy was the primary outcome. Endometrial thickness was the main measured variable. The risk factors of ectopic pregnancy were eventually determined based on univariate analysis and subsequent multiple-stepwise logistic regression analysis. 1. After adjusting for confounders, endometrial thickness could independently predict ectopic pregnancy. The adjusted odd ratios for women with endometrial thickness in the ranges of < 8 mm, 8–9.9 mm, and 10–11.9 mm were 3.270 [95% confidence interval (CI), 1.113–9.605, P = 0.031], 2.758 (95% CI, 0.987–7.707, P = 0.053), and 1.456 (95% CI, 0.502–4.225, P = 0.489), respectively, when compared with those having an endometrial thickness of 12–13.9 mm. 2. Endometrial type and preparation protocol were however not identified as risk factors for ectopic pregnancy. 1. After freeze-thaw embryo transfer, risks of ectopic pregnancy were significantly higher when the endometrial thickness was < 8 mm. 2. A thin endometrial thickness could be linked with abnormal endometrial peristaltic waves or abnormal endometrial receptivity. 3. Adequate attention should therefore be paid to patients with a thin endometrial thickness to prevent EP or to achieve early diagnosis during the peri-transplantation period.
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