Single-protein nanomechanical mass spectrometry in real time.
Single-protein nanomechanical mass spectrometry in real time.
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DOI：
10.1038/nnano.2012.119
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发表时间：
2012-09
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs upon the NEMS resonator, its mass and the position-of-adsorption are determined by continuously tracking two driven vibrational modes of the device. We demonstrate the potential of multimode NEMS-based mass spectrometry by analyzing IgM antibody complexes in real-time. NEMS-MS is a unique and promising new form of mass spectrometry: it can resolve neutral species, provides resolving power that increases markedly for very large masses, and allows acquisition of spectra, molecule-by-molecule, in real-time.
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影响因子：
38.3
作者：
Li, Mo;Tang, H. X.;Roukes, M. L.
通讯作者：
Roukes, M. L.
DOI：
10.1109/proc.1966.4634
发表时间：
1966-01-01
期刊：
PROCEEDINGS OF THE INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS
影响因子：
--
作者：
ALLAN, DW
通讯作者：
ALLAN, DW
影响因子：
3.2
作者：
Ekinci, KL;Yang, YT;Roukes, ML
通讯作者：
Roukes, ML
影响因子：
3.3
作者：
Chiang, CL;Hsu, MB;Lai, LB
通讯作者：
Lai, LB
影响因子：
48
作者：
Heck, Albert J. R.
通讯作者：
Heck, Albert J. R.