Efficient flow suppressed MRI improves interscan reproducibility of carotid atherosclerosis plaque burden measurements.
Efficient flow suppressed MRI improves interscan reproducibility of carotid atherosclerosis plaque burden measurements.
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DOI：
10.1002/jmri.22274
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发表时间：
2010-08
影响因子：
4.4
通讯作者：
Yuan, Chun
中科院分区：
文献类型：
--
作者：
Dong, Li;Wang, Jinnan;Yarnykh, Vasily L.;Underhill, Hunter R.;Neradilek, Moni B.;Polissar, Nayak;Hatsukami, Thomas S.;Yuan, Chun
To determine if better flow-suppression can meaningfully improve the reproducibility of measurements associated with carotid atherosclerotic disease, particularly for lumen and wall areas. Eighteen subjects with carotid artery stenosis identified by duplex ultrasound (11 with 16–49% stenosis; 7 with 50–79% stenosis) underwent two carotid MRI examinations on a 3T scanner with a 4-channel phased array coil. High-resolution intermediate-weighted TSE (TR/TE=4000/8.5ms, 0.55mm in-plane resolution, 2mm slice thickness, 16 slices, 3min scan time) with two different flow suppression techniques (mDIR and MSDE) were obtained separately. For each subject, bilateral arteries were reviewed. One radiologist blinded to time points, flow suppression techniques, and clinical information, measured the arterial lumen area, wall area and total vessel wall area. Compared to mDIR, the MSDE technique had a smaller inter-scan standard deviation (SD) in lumen (SD: 3.6 vs. 5.2 mm2, p=0.02), wall area measurements (SD: 4.5 vs. 6.4 mm2, p=0.02) and total vessel area measurement (SD: 4.4 vs. 4.9 mm2, p=0.07), and a trend towards smaller SD in total vessel area measurement (SD: 4.4 vs. 4.9 mm2, p=0.07). The results from this study demonstrated that vessel wall imaging could quantify atherosclerotic plaque measurements more reliably with improved blood suppression technique. This relationship between flow suppression efficiency and reproducibility of plaque measurements is important as more reliable area measurements will be useful in clinical diagnosis and in serial MRI studies that monitor carotid atherosclerotic lesion progression and regression.
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影响因子：
4.8
作者：
Underhill, Hunter R.;Yuan, Chun;Hatsukami, Thomas S.
通讯作者：
Hatsukami, Thomas S.
影响因子：
24
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通讯作者：
Badimon, JJ
影响因子：
8.3
作者：
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通讯作者：
Hatsukami, TS
影响因子：
37.8
作者：
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通讯作者：
Yuan, C
影响因子：
5
作者：
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通讯作者：
Bluemke, DA