Neutrophil responses to injury or inflammation impair peripheral gustatory function.
Neutrophil responses to injury or inflammation impair peripheral gustatory function.
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DOI：
10.1016/j.neuroscience.2010.02.056
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发表时间：
2010-05-19
期刊：
影响因子：
3.3
通讯作者：
McCluskey LP
中科院分区：
文献类型：
--
作者：
Steen PW;Shi L;He L;McCluskey LP
成人外周味觉系统在受伤后具有广泛的功能可塑性。切断鼓索 (CT)（一种主要的感觉传入神经）会引起未受伤的对侧味觉感受器细胞群的短暂变化。值得注意的是，这些缺陷是钠转导途径特有的。完整神经的正常功能很快恢复，同时巨噬细胞涌入舌头的去神经侧和未受伤侧。然而，通过限制钠来改变饮食环境会阻碍巨噬细胞反应并延长功能改变。由于功能缺陷发生在巨噬细胞出现在外周味觉系统之前，我们假设中性粒细胞在调节完整 CT 中的神经反应中发挥作用。首先，在对照组和缺钠大鼠中分析中性粒细胞对神经损伤反应的动态。神经切片短暂地增加了舌头去神经侧和未受伤侧的中性粒细胞数量。低钠饮食放大并延长了双侧中性粒细胞对损伤的反应，同时钠味觉功能持续变化。为了测试中性粒细胞对味觉功能的影响，我们在神经切片之前耗尽了这些细胞，并记录了完整 CT 的神经反应。这种治疗恢复了未受伤神经的正常钠反应。此外，将中性粒细胞募集到舌头会导致两个 CT 神经的钠味觉功能缺陷。中性粒细胞在口腔持续的炎症反应中发挥着关键作用，并可能引起味觉的变化。我们还认为，平衡的中性粒细胞和巨噬细胞反应能够在神经损伤后实现正常的神经反应。
The adult peripheral taste system is capable of extensive functional plasticity after injury. Sectioning the chorda tympani (CT), a primary sensory afferent nerve, elicits transient changes in the uninjured, contralateral population of taste receptor cells. Remarkably, the deficits are specific to the sodium transduction pathway. Normal function is quickly restored in the intact nerve, in parallel with an influx of macrophages to both the denervated and uninjured sides of the tongue. However, changing the dietary environment by restricting sodium blocks the macrophage response and prolongs functional alterations. Since the functional deficits occur before macrophages are present in the peripheral taste system, we hypothesized that neutrophils play a role in modulating neural responses in the intact CT. First, the dynamics of the neutrophil response to nerve injury were analyzed in control-fed and sodium-deficient rats. Nerve sectioning briefly increased the number of neutrophils on both the denervated and uninjured sides of the tongue. The low-sodium diet amplified and extended the bilateral neutrophil response to injury, in parallel with the persistent changes in sodium taste function. To test the impact of neutrophils on taste function, we depleted these cells prior to nerve sectioning and recorded neural responses from the intact CT. This treatment restored normal sodium responses in the uninjured nerve. Moreover, recruiting neutrophils to the tongue induced deficits in sodium taste function in both CT nerves. Neutrophils play a critical role in ongoing inflammatory responses in the oral cavity, and may induce changes in taste perception. We also suggest that balanced neutrophil and macrophage responses enable normal neural responses after neural injury.
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影响因子：
4.2
作者：
Cavallin, MA;McCluskey, LP
通讯作者：
McCluskey, LP
影响因子：
7.4
作者：
Bennett, G;al-Rashed, S;Brain, SD
通讯作者：
Brain, SD
影响因子：
5
作者：
Choi, Jae Young;Choi, Yoon-Seok;Yoon, Joo-Heon
通讯作者：
Yoon, Joo-Heon
影响因子：
15.9
作者：
HILL, DL;MISTRETTA, CM
通讯作者：
MISTRETTA, CM
DOI：
10.1152/ajpregu.00219.2009
发表时间：
2009-10-01
影响因子：
2.8
作者：
Guagliardo, Nick A.;West, Katie Nicole;Hill, David L.
通讯作者：
Hill, David L.