The development of human amygdala functional connectivity at rest from 4 to 23 years: a cross-sectional study.
The development of human amygdala functional connectivity at rest from 4 to 23 years: a cross-sectional study.
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DOI：
10.1016/j.neuroimage.2014.03.038
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发表时间：
2014-07-15
期刊：
影响因子：
5.7
通讯作者：
Tottenham N
中科院分区：
文献类型：
--
作者：
Gabard-Durnam LJ;Flannery J;Goff B;Gee DG;Humphreys KL;Telzer E;Hare T;Tottenham N
杏仁核与皮层和皮层下区域之间的功能连接（FC）是一系列情感和认知过程的基础。尽管杏仁核网络在这些功能中发挥着重要作用，但杏仁核和大脑其他部分之间FC的规范性发育出现仍然在很大程度上不确定。本研究采用杏仁核亚区地图和静息态功能磁共振成像来表征4至23岁（n = 58）人类杏仁核FC的典型发育。杏仁核FC与皮质下和边缘系统的地区是在很大程度上稳定的整个发展时期。然而，三个皮层区域表现出年龄依赖性的变化，在FC：杏仁核FC与内侧前额叶皮层（mPFC）随着年龄的增长而增加，而杏仁核FC的一个地区，包括颞叶和上级颞沟随着年龄的增长而下降，杏仁核FC的一个地区，包括海马旁回和后扣带回也随着年龄的增长而下降。从儿童期到青春期（10岁左右）的过渡标志着杏仁核皮质FC的性质的一个重要的变化点。我们区分独特的发展模式的耦合杏仁核三个分区，并发现特别强大的收敛FC与mPFC的所有分区。这些发现表明，在童年和青春期之间，杏仁核-皮质功能连接发生了广泛的变化。
Functional connections (FC) between the amygdala and cortical and subcortical regions underlie a range of affective and cognitive processes. Despite the central role amygdala networks have in these functions, the normative developmental emergence of FC between the amygdala and the rest of the brain is still largely undefined. This study employed amygdala subregion maps and resting-state functional magnetic resonance imaging to characterize the typical development of human amygdala FC from age 4 to 23 years old (n = 58). Amygdala FC with subcortical and limbic regions was largely stable across this developmental period. However, three cortical regions exhibited age-dependent changes in FC: amygdala FC with the medial prefrontal cortex (mPFC) increased with age, while amygdala FC with a region including the insula and superior temporal sulcus decreased with age, and amygdala FC with a region encompassing the parahippocampal gyrus and posterior cingulate also decreased with age. The transition from childhood to adolescence (around age 10 years) marked an important change-point in the nature of amygdala-cortical FC. We distinguished unique developmental patterns of coupling for three amygdala subregions and found particularly robust convergence of FC for all subregions with the mPFC. These findings suggest that there are extensive changes in amygdala-cortical functional connectivity that emerge between childhood and adolescence.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
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影响因子：
3.2
作者：
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影响因子：
5.7
作者：
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通讯作者：
Deco, Gustavo
影响因子：
3.3
作者：
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