Prodromal psychosis detection in a counseling center population in China: an epidemiological and clinical study.
Prodromal psychosis detection in a counseling center population in China: an epidemiological and clinical study.
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中国咨询中心人群的前驱精神病检测：一项流行病学和临床研究
DOI：
10.1016/j.schres.2013.11.039
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发表时间：
2014-02
影响因子：
4.5
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang T;Li H;Woodberry KA;Seidman LJ;Zheng L;Li H;Zhao S;Tang Y;Guo Q;Lu X;Zhuo K;Qian Z;Chow A;Li C;Jiang K;Xiao Z;Wang J
通过两阶段临床筛查，调查中国求助样本中精神病综合征风险的频率和临床特征。在上海精神卫生中心 (SMHC) 首次就诊时连续招募了 2101 名 15-45 岁的新患者，并使用前驱问卷简明版 (PQ-B) 和有关遗传风险的问题进行筛查。对子样本进行前驱综合症结构化访谈 (SIPS)，以估计精神病发生率和精神病综合症的临床高风险 (CHR)。总样本中 CHR 综合征的频率估计为 4.2%。在 89 名 CHR 患者中，超过三分之二符合减弱阳性症状综合征 (APSS) 的标准；近四分之一符合遗传风险和恶化综合症（GRDS）的标准。 CHR 综合征的发生率在 16-21 岁之间达到峰值，并随着年龄的增长而下降。患有 APSS 和精神病的受试者的 PQ-B 平均总分和痛苦评分显着高于患有 GDRS 的个体和没有精神病或 CHR 的患者。在 SIPS 访谈中发现一些阳性和非特异性症状之间存在高频率和强相关性。在随访两年的 53 名 CHR 参与者中，14 人（26.4%）转变为精神病。在未转化者中，53.8% 被诊断患有轴 I 疾病。这种两阶段筛查方法可以增强临床环境中对中国 CHR 患者的检测。检测 CHR 程序的有效性得到了精神病转变率和非转化性 Axis I 障碍的比率的支持，这些比率与荟萃分析中报告的结果相当。
To investigate through a two-stage clinic-based screening, the frequency and clinical features of risk for psychosis syndromes in a Chinese help-seeking sample. 2101 consecutive new patients ages 15–45 were recruited at their first visit to the Shanghai Mental Health Center (SMHC) and screened with the Prodromal Questionnaire -brief version (PQ-B) and questions about genetic risk. The Structured Interview for Prodromal Syndromes (SIPS) was administered to a sub-sample to estimate rates of psychosis and clinical high risk (CHR) for psychosis syndromes. The frequency estimate of CHR syndromes in the total sample was 4.2%. Among 89 CHR patients, more than two-thirds met criteria for Attenuated Positive Symptom Syndrome (APSS); and nearly a quarter met the criteria for Genetic Risk and Deterioration Syndrome (GRDS). The frequency of CHR syndromes peaked between the ages of 16–21 years and declined with subsequent age. The mean total and distress scores on the PQ-B in subjects with APSS and psychosis were significantly higher than in individuals with GDRS and patients without psychosis or CHR. High frequencies and strong correlations were found among some positive and non-specific symptoms in SIPS interviews. Among the 53 CHR participants who were followed-up for two years, 14 (26.4%) converted to psychosis. Of the non-converters, 53.8% were diagnosed with Axis I disorders. This two stage screening method can enhance detection of Chinese CHR patients in clinical settings. The validity of the procedures for detecting CHR is supported by rates of transition to psychosis and of non-converter Axis I disorders that are comparable to those reported in meta-analyses.
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影响因子：
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作者：
Klosterkötter, J;Hellmich, M;Schultze-Lutter, F
通讯作者：
Schultze-Lutter, F
影响因子：
6.6
作者：
McGlashan, Thomas H.;Addington, Jean;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
6.9
作者：
Green, C. E. L.;McGuire, P. K.;Valmaggia, L. R.
通讯作者：
Valmaggia, L. R.
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
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Yung, Alison
影响因子：
11.9
作者：
Hsiao, MC;Liu, CY;Yeh, EK
通讯作者：
Yeh, EK