Small DNA Methylation, Big Player in Plant Abiotic Stress Responses and Memory.
Small DNA Methylation, Big Player in Plant Abiotic Stress Responses and Memory.
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小 DNA 甲基化，植物非生物应激反应和记忆的重要参与者
DOI：
10.3389/fpls.2020.595603
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发表时间：
2020
影响因子：
5.6
通讯作者：
He Z
中科院分区：
文献类型：
--
作者：
Liu J;He Z
DNA甲基化是一种保守的表观遗传标记，在维持基因组稳定和调控基因表达方面起着重要作用。作为固着生物，植物已经进化出复杂的调节系统来忍受或响应各种不利的非生物环境挑战，即，非生物胁迫，如极端温度（寒冷和炎热）、干旱和盐碱。植物胁迫反应通常伴随着不同响应位点的染色质修饰的变化，例如5-甲基胞嘧啶（5 mC）和N6-甲基腺嘌呤（6 mA）DNA甲基化。一些非生物胁迫反应通过有丝分裂细胞分裂记忆数小时或数天，并在恢复正常条件后迅速重置到基线水平，这被称为体细胞记忆。在某些情况下，胁迫诱导的染色质标记是减数分裂可遗传的，并且可以通过跨代表观遗传的机制将来自亲本植物的胁迫暴露的记忆传递给至少下一个无胁迫的后代，这可以为后代提供适应性更好的适应性的潜力。本文简要综述了近年来DNA甲基化的建立、维持和重置的研究进展，并重点介绍了DNA甲基化在植物非生物胁迫响应中的不同作用。此外，我们还讨论了DNA甲基化在非生物胁迫诱导的体细胞记忆和跨代遗传中的潜在作用。并提出了今后的研究方向，即开发抗逆基因工程作物以减轻非生物胁迫的负面影响。
DNA methylation is a conserved epigenetic mark that plays important roles in maintaining genome stability and regulating gene expression. As sessile organisms, plants have evolved sophisticated regulatory systems to endure or respond to diverse adverse abiotic environmental challenges, i.e., abiotic stresses, such as extreme temperatures (cold and heat), drought and salinity. Plant stress responses are often accompanied by changes in chromatin modifications at diverse responsive loci, such as 5-methylcytosine (5mC) and N6-methyladenine (6mA) DNA methylation. Some abiotic stress responses are memorized for several hours or days through mitotic cell divisions and quickly reset to baseline levels after normal conditions are restored, which is referred to as somatic memory. In some cases, stress-induced chromatin marks are meiotically heritable and can impart the memory of stress exposure from parent plants to at least the next stress-free offspring generation through the mechanisms of transgenerational epigenetic inheritance, which may offer the descendants the potential to be adaptive for better fitness. In this review, we briefly summarize recent achievements regarding the establishment, maintenance and reset of DNA methylation, and highlight the diverse roles of DNA methylation in plant responses to abiotic stresses. Further, we discuss the potential role of DNA methylation in abiotic stress-induced somatic memory and transgenerational inheritance. Future research directions are proposed to develop stress-tolerant engineered crops to reduce the negative effects of abiotic stresses.
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影响因子：
3.7
作者：
Boyko A;Blevins T;Yao Y;Golubov A;Bilichak A;Ilnytskyy Y;Hollunder J;Meins F Jr;Kovalchuk I
通讯作者：
Kovalchuk I
影响因子：
10.5
作者：
Bartee, L;Malagnac, F;Bender, J
通讯作者：
Bender, J
影响因子：
6.9
作者：
Chwialkowska K;Nowakowska U;Mroziewicz A;Szarejko I;Kwasniewski M
通讯作者：
Kwasniewski M
影响因子：
13.6
作者：
Crisp PA;Ganguly D;Eichten SR;Borevitz JO;Pogson BJ
通讯作者：
Pogson BJ
影响因子：
64.5
作者：
Calarco JP;Borges F;Donoghue MT;Van Ex F;Jullien PE;Lopes T;Gardner R;Berger F;Feijó JA;Becker JD;Martienssen RA
通讯作者：
Martienssen RA