Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures.
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures.
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DOI：
10.1126/sciadv.abd4639
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发表时间：
2021-01
期刊：
影响因子：
13.6
通讯作者：
Kim DH
中科院分区：
文献类型：
--
作者：
Joo H;Lee Y;Kim J;Yoo JS;Yoo S;Kim S;Arya AK;Kim S;Choi SH;Lu N;Lee HS;Kim S;Lee ST;Kim DH
开发了一种与可穿戴设备无线集成的软性植入式药物输送装置，用于治疗致命癫痫发作。个性化生物医学设备在解决紧急医疗情况下的临床挑战方面具有巨大的潜力。尽管有这种潜力，但尚未开发出一种使用药物方法原位治疗致命癫痫发作的装置。在这里，我们提出了一种新的治疗系统，用于神经医学紧急情况，如癫痫持续状态，一种需要立即治疗的致命癫痫状态，使用软植入式药物输送装置（SID）。SID与可穿戴设备无线集成，用于监测脑电图信号，并通过无线电压感应触发皮下药物释放。由于无线集成，笨重的刚性组件，如传感器、电池和电子电路可以从SID移动到可穿戴设备，从而实现SID的机械柔软性和小型化。及时治疗的有效性可以通过动物体内实验得到证实，减少了脑损伤，提高了生存率。
A soft implantable drug delivery device integrated wirelessly with wearable devices was developed to treat fatal seizures. Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.
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