Display of peptides on the surface of tobacco mosaic virus particles.
Display of peptides on the surface of tobacco mosaic virus particles.
复制标题
DOI：
10.1007/978-3-540-70868-1_2
复制
发表时间：
2009
影响因子：
--
通讯作者：
Palmer KE
中科院分区：
文献类型：
--
作者：
Smith ML;Fitzmaurice WP;Turpen TH;Palmer KE
In this review, we focus on the potential that tobacco mosaic virus (TMV) has as a carrier for immunogenic epitopes, and the factors that must be considered in order to bring products based on this platform to the market. Large Scale Biology Corporation developed facile and scaleable methods for manufacture of candidate peptide display vaccines based on TMV. We describe how rational design of peptide vaccines can improve the manufacturability of particular TMV products. We also discuss downstream processing and purification of the vaccine products, with particular attention to the metrics that a product must attain in order to meet criteria for regulatory approval as injectable biologics.
登录
查看更多内容
影响因子：
3.8
作者：
CLARKE, BE;BROWN, AL;FRANCIS, MJ
通讯作者：
FRANCIS, MJ
影响因子：
5.5
作者：
FITCHEN, J;BEACHY, RN;HEIN, MB
通讯作者：
HEIN, MB
影响因子：
3.1
作者：
BLACKBURN, NK;BESSELAAR, TG
通讯作者：
BESSELAAR, TG
DOI：
10.1073/pnas.83.6.1832
发表时间：
1986-03-01
影响因子：
11.1
作者：
DAWSON, WO;BECK, DL;GRANTHAM, GL
通讯作者：
GRANTHAM, GL
影响因子：
46.9
作者：
Dalsgaard, K;Uttenthal, A;Rodgers, PB
通讯作者：
Rodgers, PB