Ecoimmunology for psychoneuroimmunologists: Considering context in neuroendocrine-immune-behavior interactions.
Ecoimmunology for psychoneuroimmunologists: Considering context in neuroendocrine-immune-behavior interactions.
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DOI：
10.1016/j.bbi.2014.09.002
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发表时间：
2015-02
影响因子：
15.1
通讯作者：
Carlton, Elizabeth D.
中科院分区：
文献类型：
--
作者：
Demas, Gregory E.;Carlton, Elizabeth D.
免疫学的研究已经成为传统免疫学学科之外的广泛领域的研究人员的重要研究领域。在过去的几十年里，心理神经免疫学（PNI）一直致力于确定神经，内分泌和免疫系统与行为之间的关键相互作用。最近，生态免疫学（ecoimmunology）领域已经在生态学和进化生物学的视角下建立，与PNI分享了环境对免疫功能的影响。生态免疫学的主要目标是在广泛整合的有机体背景下，通常从最终的进化角度来理解免疫功能。为了实现这一点，生态免疫学，像PNI一样，已经成为一个广泛综合的研究领域，结合了从进化和生态学到内分泌学和神经生物学的各种方法。PNI和生态免疫学的学科，以其独特而互补的观点和方法，有很多可以提供彼此。然而，这两个领域的研究人员尽管试图整合，但在很大程度上仍然不知道对方的发现。这篇综述的目的是与心理神经免疫学家和其他机械导向的研究人员分享一些核心概念和原则，以及相关的最新研究结果，希望这些信息将证明与他们自己的研究计划相关。更广泛地说，我们的目标是试图将PNI和生态免疫学分别提供的近端和最终视角整合到一个共同的理论框架中，以了解更大的生态，进化背景下的神经-内分泌-免疫相互作用和行为。
The study of immunity has become an important area of investigation for researchers in a wide range of areas outside the traditional discipline of immunology. For the last several decades, psychoneuroimmunology (PNI) has strived to identify key interactions among the nervous, endocrine and immune systems and behavior. More recently, the field of ecological immunology (ecoimmunology) has been established within the perspectives of ecology and evolutionary biology, sharing with PNI an appreciation of the environmental influences on immune function. The primary goal of ecoimmunology is to understand immune function within a broadly integrative, organismal context, typically from an ultimate, evolutionary perspective. To accomplish this ecoimmunology, like PNI, has become a broadly integrative field of investigation, combining diverse approaches from evolution and ecology to endocrinology and neurobiology. The disciplines of PNI and ecoimmunology, with their unique yet complementary perspectives and methodologies, have much to offer one another. Researchers in both fields, however, remain largely unaware of each other's findings despite attempts at integration. The goal of this review is to share with psychoneuroimmunologists and other mechanistically-oriented researchers some of the core concepts and principles, as well as relevant recent findings, within ecoimmunology with the hope that this information will prove relevant to their own research programs. More broadly, our goal is to attempt to integrate both the proximate and ultimate perspectives offered by PNI and ecoimmunology respectively into a common theoretical framework for understanding neuro-endocrine-immune interactions and behavior in a larger ecological, evolutionary context.
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DOI：
10.1098/rspb.2005.3126
发表时间：
2005-09-07
影响因子：
4.7
作者：
Demas, GE;Sakaria, S
通讯作者：
Sakaria, S
影响因子：
2.9
作者：
Buehler, Deborah M.;Piersma, Theunis;Tieleman, B. Irene
通讯作者：
Tieleman, B. Irene
影响因子：
2.6
作者：
Adamo, Shelley A.
通讯作者：
Adamo, Shelley A.
影响因子：
1.6
作者：
Beechler, Brianna R.;Broughton, Heather;Jolles, Anna E.
通讯作者：
Jolles, Anna E.
影响因子：
3.5
作者：
Demas, GE
通讯作者：
Demas, GE