Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients
Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients
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循环 S100A8/A9 水平反映葡萄膜炎患者的眼内炎症
DOI：
10.1080/09273948.2018.1538461
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发表时间：
2018-11
影响因子：
3.3
通讯作者：
Zai-Long Chi
中科院分区：
文献类型：
--
作者：
Yu-Qin Wang;Xiao-Dan Dai;Yun Ran;Ying Cao;Chun-Lin Lan;Ji-Tian Guan;Chang Liu;Feng-Mei Yang;Yi-Jing Gan;Bai-Jing Liu;Ai-Wu Fang;Dan Lin;Xian-Hui Gong;Ren-Zhe Cui;Zi-Bing Jin;Jia Qu;Fan Lu;Zai-Long Chi
摘要 目的：调查循环 S100A8/A9 水平与葡萄膜炎活动之间是否存在关联。方法：从葡萄膜炎患者和非葡萄膜炎对照中收集了总共 549 份血浆样本。结果：与非葡萄膜炎对照组相比，葡萄膜炎患者的 S100A8/A9 血浆水平升高（P < 0.001）。活动性急性前葡萄膜炎 (AAU) 患者的 S100A8/A9 血浆水平在皮质类固醇治疗后随眼内炎症的严重程度显着升高和显着降低 (P < 0.001)。患有强直性脊柱炎 (AS) 的 AAU 患者的 S100A8/A9 血浆水平也高于无 AS 的患者 (P = 0.02)。与 CRP 或 ESR 值正常的葡萄膜炎患者相比，C 反应蛋白（CRP，P = 0.004）或红细胞沉降率（ESR，P = 0.049）水平升高的葡萄膜炎患者的 S100A8/A9 血浆水平显着升高。结论：循环 S100A8/A9 可能是测量眼内炎症的有用生物标志物。
ABSTRACT Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values. Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.
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影响因子：
--
作者：
Zai-Long Chi;Xiaodan Dai
通讯作者：
Zai-Long Chi;Xiaodan Dai
影响因子：
16.6
作者：
Pickering, Tim;Hamm, Joachim M.;Page, A. Freddie;Wuestner, Sebastian;Hess, Ortwin
通讯作者：
Hess, Ortwin
影响因子：
3.4
作者：
Chi, Zai-Long;Hayasaka, Yoriko;Hayasaka, Seiji
通讯作者：
Hayasaka, Seiji
影响因子：
17.8
作者：
Willermain F;Rosenbaum JT;Bodaghi B;Rosenzweig HL;Childers S;Behrend T;Wildner G;Dick AD
通讯作者：
Dick AD
影响因子：
4.1
作者：
Kim, Duk Hwan;Park, Yehyun;Cheon, Jae Hee
通讯作者：
Cheon, Jae Hee